Iron-sulfur (Fe-S) clusters are small inorganic cofactors formed by tetrahedral coordination of iron atoms with sulfur groups. Present in numerous proteins, these clusters are involved in key biological processes such as ...

Synthesis of the iron-containing prosthetic groups—heme and iron–sulfur clusters—occurs in mitochondria. The mitochondrion is also an important producer of reactive oxygen species (ROS), which are derived fromelectrons leaking ...

Assembly and stabilization of a glutathione-complexed [2Fe–2S] cluster is promoted by aggregation of glutathione. The cluster core selects the tetramer species from a collection of equilibrating solution aggregate ...

We report results of Xα valence bond scattered wave (Xα-VB-SW) calculations for a variety of clusters that mimic the active sites in iron-sulfur proteins: Fe(SR)41-,2- (R = H, CH3), Fe2S2(SH)42-,3-, and Fe4S4(SCH3)42-,3-. ...

Mammalian frataxin is a small mitochondrial protein involved in iron sulfur cluster assembly. Frataxin deficiency causes the neurodegenerative disease Friedreich´s Ataxia. Valuable knowledge has been gained on the structural ...

Several biological activities depend on iron–sulfur clusters ([Fe-S]). Even though they are well-known in several organisms their function and metabolic pathway were poorly understood in the majority of the organisms. We ...

The ability to conserve energy in the presence or absence of oxygen provides a metabolic versatility that confers an advantage in natural ecosystems. The switch between alternative electron transport systems is controlled ...

Acidithiobacillus ferrooxidans obtains its energy from the oxidation of ferrous iron, elemental sulfur, or partially oxidized sulfur compounds. The ability of this microorganism to solubilize metal sulfides is successfully ...

The molybdenum nitrogenase, present in a diverse group of bacteria and archea, is the major contributor to biological nitrogen fixation. The nitrogenase active site contains an iron-molybdenum cofactor (FeMo-co) composed ...