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Fatty acid regulation of voltage- and ligand-gated ion channel function
(Frontiers Research Foundation, 2016-11-28)
Free fatty acids (FFA) are essential components of the cell, where they play a key role in lipid and carbohydrate metabolism, and most particularly in cell membranes, where they are central actors in shaping the physicochemical ...
A chloride channel from human placenta reconstituted into giant liposomes
(Mosby-Year book, 1995)
OBJECTIVE: Ion channels play important roles in epithelial transport, but they are difficult to access for conventional electrophysiologic studies in intact placenta. The purpose of this work was to explore the suitability ...
Ion channels from chemosensory olfactory neurons
(Kluwer Academic Publishers-Plenum Publishers, 1988)
The olfactory epithelium has the ability to respond to a large number of volatile compounds of small molecular weight. Ultimately, such a property lies on a specialized type of neuron, the olfactory receptor cell. In the ...
Phylogenetic conservation of protein-lipid motifs in pentameric ligand-gated ion channels
(Elsevier Science, 2015-07)
Using the crosstalk between the nicotinic acetylcholine receptor (nAChR) and its lipid microenvironment as a paradigm, this short overview analyzes the occurrence of structural motifs which appear not only to be conserved ...
A change in the ion selectivity of ligand-gated ion channels provides a mechanism to switch behavior.
(Public Library Of Science, 2015-09)
Behavioral output of neural networks depends on a delicate balance between excitatory and inhibitory synaptic connections. However, it is not known whether network formation and stability is constrained by the sign of ...
Bridging behavior and physiology: Ion-channel perspective on mushroom body-dependent olfactory learning and memory in Drosophila
(WILEY-LISS, DIV JOHN WILEY & SONS, 2006-12)
An important body of evidence documents the differential expression of ion channels in brains, suggesting they are essential to endow particular brain structures with specific physiological properties. Because of their ...
Novel model of calcium and inositol 1,4,5-trisphosphate regulation of InsP3 receptor channel gating in native endoplasmic reticulum
(Sociedad de Biología de Chile, 2004)
Coupling of voltage-dependent gating and Ba++ block in the high-conductance, Ca++-activated K+ channel
(1987)
Voltage-dependent Ca++-activated K+ channels from rat skeletal muscle were reconstituted into planar lipid bilayers, and the kinetics of block of single channels by Ba++ were studied. The Ba++ association rate varies ...
Effect of the gadolinium ion on body fluid regulation
(Elsevier, 2003)
Both osmoreception and baroreception are thought to involve ion channels that are sensitive to changes in membrane stretch. We investigated the effect of a blocker of stretch-activated ion channels, the Gd3+ ion, on ...
A Latin American perspective on ion channels
(American Society for Pharmacology and Experimental Therapeutics, 2016-09)
Ion channels, both ligand- And voltage-gated, play fundamental roles in many physiologic processes. Alteration in ion channel function underlies numerous pathologies, including hypertension, diabetes, chronic pain, epilepsy, ...