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Iodide handling disorders (NIS, TPO, TG, IYD)
(Elsevier, 2017-03)
Iodide Handling Disorders lead to defects of the biosynthesis of thyroid hormones (thyroid dyshormonogenesis, TD) and thereafter congenital hypothyroidism (CH), the most common endocrine disease characterized by low levels ...
Monoallelic thyroid peroxidase gene mutation in a patient with congenital hypothyroidism with total iodide organification defectMutação monoalélica no gene da tireoperoxidase em paciente com hipotireoidismo congênito com defeito total de incorporação de iodeto
(Sociedade Brasileira de Endocrinologia e Metabologia, 2010-11)
The aim of this study was to identify the genetic defect of a patient with dyshormonogenetic congenital hypothyroidisms (CH) with total iodide organification defect (TIOD). A male child diagnosed with CH during neonatal ...
A novel mutation in the TPO gene in goitrous hypothyroid patients with iodide organification defect
(Blackwell Science LtdOxfordInglaterra, 1999)
Five novel inactivating mutations in the thyroid peroxidase gene responsible for congenital goiter and iodide organification defect
(Veterinary and Human Toxicology, 2003-12)
Thyroid peroxidase (TPO) defects, typically transmitted as autosomal recessive traits, result in hypothyroid goiters with failure to convert iodide into organic iodine. We analyzed the TPO gene in 14 unrelated patients ...
Limolipin, um repressor transcricional que promove esteatose hepática
(Universidade Federal de São Paulo (UNIFESP), 2017-10-26)
Liver-specific disruption of the type 2 deiodinase gene (Alb-D2KO), that encodes the key enzyme that activates thyroid hormone, results in resistance to diet-induced obesity and to liver steatosis in mice. Here we report ...
Antibody-targeted horseradish peroxidase associated with indole-3-acetic acid induces apoptosis in vitro in hematological malignancies
(Pergamon-Elsevier B.V. Ltd, 2011-05-01)
Indole-3-acetic acid (IAA), when oxidized by horseradish peroxidase (HRP), is transformed into cytotoxic molecules capable of inducing cell injury. The aim of this study was to test if, by targeting hematopoietic tumors ...
Monoallelic thyroid peroxidase gene mutation in a patient with congenital hypothyroidism with total iodide organification defect
(Sociedade Brasileira de Endocrinologia e Metabologia, 2010)
The aim of this study was to identify the genetic defect of a patient with dyshormonogenetic congenital hypothyroidisms (CH) with total iodide organification defect (TIOD). A male child diagnosed with CH during neonatal ...
Anticorpos anti-tiróide: aspectos metodológicos e importância diagnóstica
(Sociedade Brasileira de Endocrinologia e Metabologia, 2003-10-01)
Since the first publication, more than 40 years ago, laboratory tests for the presence of antibodies (Ab) to thyroid antigens (Ag) have played a pivotal position in the diagnosis of thyroid diseases. Thyroid is a common ...
Antibody-targeted horseradish peroxidase associated with indole-3-acetic acid induces apoptosis in vitro in hematological malignancies
(PERGAMON-ELSEVIER SCIENCE LTD, 2011)
Indole-3-acetic acid (IAA), when oxidized by horseradish peroxidase (HRP), is transformed into cytotoxic molecules capable of inducing cell injury. The aim of this study was to test if, by targeting hematopoietic tumors ...