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Evidence suggesting that the angiotensin II-sensitive intracellular Ca2+ pool is reloaded from the external space in adrenal glomerulosa cells
(1999)
Adrenal glomerulosa cells prelabeled with 45Ca2+ and perifused for 10 min with 10 nM angiotensin II (AII) in a dynamic perifusion system show a biphasic response with an initial transient increase in 45Ca2+ efflux, followed ...
A lysozyme-like protein in Brucella abortus is involved in the early stages of intracellular replication
(American Society for Microbiology, 2013-03)
Secretion of proteins in Gram-negative bacteria is a high-energy consuming process that requires the translocation across two membranes and a periplasmic space composed of a mesh like layer, the peptidoglycan. To achieve ...
In silico before in vivo: How to predict the heating efficiency of magnetic nanoparticles within the intracellular space
(Nature Publishing Group, 2016-12-07)
This work aims to demonstrate the need for in silico design via numerical simulation to produce optimal Fe 3 O 4 -based magnetic nanoparticles (MNPs) for magnetic hyperthermia by minimizing the impact of intracellular ...
Intracellular and extracellular pH dynamics in the human placenta from diabetes mellitus
(2016)
The placenta is a vital organ whose function in diseases of pregnancy is altered, resulting in an abnormal supply of nutrients to the foetus. The lack of placental vasculature homeostasis regulation causes endothelial ...
Brain modularity in arthropods: individual neurons that support “what” but not “where” memories
(Society for Neuroscience, 2011-06)
Experiments with insects and crabs have demonstrated their remarkable capacity to learn and memorize complex visual features (Giurfa et al., 2001; Pedreira and Maldonado, 2003; Chittka and Niven, 2009). Such abilities are ...
Intracellular and extracellular effector activity of mouse neutrophils in response to cutaneous and visceral Leishmania parasites
(Elsevier B.V., 2019-01-01)
Neutrophils are short-lived phagocytic cells equipped with several receptors for pathogen recognition and phagocytosis and have intracellular and extracellular effector mechanisms that can inactivate pathogens. Leishmaniases ...
MHC I presentation of Toxoplasma gondii immunodominant antigen does not require Sec22b and is regulated by antigen orientation at the vacuole membrane
(Wiley VCH Verlag, 2017-07)
The intracellular Toxoplasma gondii parasite replicates within a parasitophorous vacuole (PV). T. gondii secretes proteins that remain soluble in the PV space, are inserted into PV membranes or are exported beyond the PV ...