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The dwarf mutation decreases high dose insulin responses in skeletal muscle, the opposite of effects in liver
(Elsevier Ireland, 2003-07)
The in vivo status of the proximal components of the insulin signaling system was investigated in skeletal muscle of Ames (Prop1 df/Prop1df) dwarf mice. The insulin-stimulated phosphorylation of the insulin receptor (IR) ...
Mice lacking angiotensin type 2 receptor exhibit a sex-specific attenuation of insulin sensitivity
(Elsevier Ireland, 2019-12)
The renin-angiotensin system modulates insulin action. Pharmacological stimulation of angiotensin type 2 receptor (AT2R) was shown to have beneficial metabolic effects in various animal models of insulin resistance and ...
(-)-Epicatechin improves insulin sensitivity in high fat diet-fed mice
(Elsevier Science Inc, 2016-06)
Obesity constitutes a major public health concern, being frequently associated with type 2 diabetes (T2D). Evidence from studies in humans and experimental animals suggest that consumption of the flavan-3-ol (-)-epicatechin ...
Chronic administration of the angiotensin type 2 receptor agonist C21 improves insulin sensitivity in C57BL/6 mice
(Wiley, 2018-08)
The renin–angiotensin system modulates insulin action. Angiotensin type 1 receptor exerts a deleterious effect, whereas the angiotensin type 2 receptor (AT2R) appears to have beneficial effects providing protection against ...
Role of skeletal muscle on impaired insulin sensitivity in rats fed a sucrose-rich diet: Effect of moderate levels of dietary fish oil
(Elsevier Science Inc, 2000-05)
In the present study we investigated: (1) the contribution of the skeletal muscle to the mechanisms underlying the impaired glucose homeostasis and insulin sensitivity present in dyslipemic rats fed a sucrose-rich diet ...
Insulin gene vntr genotype is associated with insulin sensitivity and secretion in infancyCLINICAL ENDOCRINOLOGY (PRINT)CLIN. ENDOCRINOL. (PRINT)
(BLACKWELL SCIENTIFIC PUBLICATIONS, 2017)
Insulin gene vntr genotype is associated with insulin sensitivity and secretion in infancyCLINICAL ENDOCRINOLOGY (PRINT)CLIN. ENDOCRINOL. (PRINT)
(BLACKWELL SCIENTIFIC PUBLICATIONS, 2017)
Skeletal muscle triglycerides, diacylglycerols, and ceramides in insulin resistance: Another paradox in endurance-trained athletes?
(American Diabetes Association, 2011-10)
OBJECTIVE - Chronic exercise and obesity both increase intramyocellular triglycerides (IMTGs) despite having opposing effects on insulin sensitivity. We hypothesized that chronically exercisetrained muscle would be ...
The Mas receptor mediates modulation of insulin signaling by angiotensin-(1-7)
(Elsevier Science, 2012-08)
Angiotensin (Ang)-(1-7) stimulates proteins belonging to the insulin signaling pathway and ameliorates the Ang II negative effects at this level. However, up to date, receptors involved and mechanisms behind these observations ...