Now showing items 1-10 of 5208
Cistatinas de maqui: produção recombinante e inibição de cisteíno peptidases
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Genética Evolutiva e Biologia Molecular - PPGGEvCâmpus São Carlos, 2022-02-15)
Cystatins are tight binding competitive inhibitors of cysteine peptidases. In plants, they act regulating different physiological mechanisms, as well as defending from biotic and abiotic stresses, making them of potential ...
Evaluation of the biological activity of the disintegrin-like and cysteine-rich domains of Bothropasin, a metalloproteinase from Bothrops jararaca
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Química - PPGQCâmpus São Carlos, 2021-05-17)
Bothropasin is a 48kDa hemorrhagic class III Snake Venom Metalloproteinase (SVMP). As a multi-domain protein, it contains catalytic metalloproteinase (M), disintegrin-like (D), and cysteine rich domains (C). Integrins ...
Synthesis, characterization and cytotoxicity of Pd(II) complexes for the inhibition of cathepsin B
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Química - PPGQCâmpus São Carlos, 2021-12-13)
Cancer is one of the most dreaded diseases of the 20th century, and its prevalence and incidence are increasing in the 21st century. The situation is so serious that one in four people can develop cancer in their lifetime. ...
Caracterização Farmacológica da Inibição Pré-Pulso ("Prepulse Inhibition of Startle") na Linhagem SHR (Spontaneously Hypertensive Rats): Possíveis Implicações para Transtornos Psiquiátricos
(Universidade Federal de São Paulo (UNIFESP), 2009-04-29)
Deficits in an operational measure of sensorimotor gating - the prepulse inhibition of startle (PPI) - is presented in psychiatric disorders such as schizophrenia, bipolar disorder, and attention deficit/hyperactivity ...
Busca de inibidores da catepsina K em plantas medicinais utilizadas no tratamento de doenças osteoarticulares
(Universidade Federal de São CarlosBRUFSCarPrograma de Pós-Graduação em Química - PPGQ, 2011-09-26)
Ten herbs used in traditional medicine supported by literature for its effectiveness to osteoarticular diseases were selected to conduct a screening of inhibition activity against the cathepsin K, an important enzyme ...