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Glucose-induced insulin secretion is impaired and insulin-induced phosphorylation of the insulin receptor and insulin receptor substrate-1 are increased in protein-deficient rats
(1997-03-01)
Malnutrition is related to diabetes in tropical countries. In experimental animals, protein deficiency may affect insulin secretion. However, the effect of malnutrition on insulin receptor phosphorylation and further ...
Islet adaptive changes to fructose-induced insulin resistance: β-cell mass, glucokinase, glucose metabolism, and insulin secretion
(BioScientifica, 2009-02)
β-Cell mass, hexokinase/glucokinase (HK/GK) activity, glucose metabolism and insulin secretion were studied in the islets of rats with fructose-induced insulin resistance (IR). Normal male Wistar rats were fed a standard ...
Functional alterations in endocrine pancreas of rats with different degrees of dexamethasone-induced insulin resistance
(Lippincott Williams & Wilkins, 2008-04-01)
Objectives: We have analyzed the peripheral insulin and glucose sensitivity in vivo, and islet function ex vivo in rats with different degrees of insulin resistance induced by dexamethasone (DEX).Methods: Dexamethasone, ...
Functional alterations in endocrine pancreas of rats with different degrees of dexamethasone-induced insulin resistance
(Lippincott Williams & Wilkins, 2008-04-01)
Objectives: We have analyzed the peripheral insulin and glucose sensitivity in vivo, and islet function ex vivo in rats with different degrees of insulin resistance induced by dexamethasone (DEX).Methods: Dexamethasone, ...
Role of Islet Glucokinase, Glucose Metabolism, and Insulin Pathway in the Enhancing Effect of Islet Neogenesis-Associated Protein on Glucose-Induced Insulin Secretion
(Lippincott Williams, 2015-08)
Objective: To demonstrate the role of islet glucokinase, glucose metabolism, and intracellular insulin mediators in the enhancing effect of islet neogenesis-associated protein pentadecapeptide (INGAP-PP) on glucoseinduced ...
Involvement of the cholinergic pathway in glucocorticoid-induced hyperinsulinemia in rats
(Elsevier Ireland LtdClareIrlanda, 2010)
Restored insulin inhibition on insulin secretion in nondiabetic severely obese patients after weight loss induced by bariatric surgery
(Nature Publishing GroupLondonInglaterra, 2003)
Normal insulin sensitivity in lean offspring of obese parents
(North Amer Assoc Study ObesitySilver SpringEUA, 2004)
Involvement of the cholinergic pathway in glucocorticoid-induced hyperinsulinemia in rats
(Elsevier B.V., 2010-02-01)
Aims: We investigated the contribution of the cholinergic nervous system to dexamethasone-induced insulin resistance and hyperinsulinemia in rats.Methods: Seventy-day-old Wistar male rats were distributed in groups: control ...