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The Epstein-Barr Virus Hacks Immune Checkpoints: Evidence and Consequences for Lymphoproliferative Disorders and Cancers
(2022-03-01)
The Epstein-Barr Virus (EBV) is a gammaherpesvirus involved in the etiopathogenesis of a variety of human cancers, mostly of lymphoid and epithelial origin. The EBV infection participates in both cell transformation and ...
Galectins: emerging regulatory checkpoints linking tumor immunity and angiogenesis
(Elsevier, 2017-01)
Immune checkpoints, a plethora of inhibitory pathways aimed at maintaining immune cell homeostasis, may be co-opted by cancer cells to evade immune destruction. Therapies targeting immune checkpoints have reached a momentum ...
Making Targeted Therapy Compatible with Checkpoint Immunotherapy
(Elsevier Science London, 2017-07)
Immune checkpoint blockades induced by antibodies are revolutionizing cancer therapy. Combinations of checkpoint immunotherapies with kinase inhibitors (KIs) are being clinically evaluated as oncogenic mutations arise. ...
Immune checkpoints pathways in head and neck squamous cell carcinoma
(MDPI, 2021-03)
Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of tumors usually diagnosed at an advanced stage and characterized by a poor prognosis. The main risk factors associated with its development include ...
Role of inflammasome activation in tumor immunity triggered by immune checkpoint blockers
(Wiley Blackwell Publishing, Inc, 2020-03)
Immune checkpoint blockers improve the overall survival of a limitednumber of patients among different cancers. Identifying pathways thatinfluence the immunological and clinical response to treatment is criticalto improve ...
Immune checkpoints and the regulation of tolerogenicity in dendritic cells: Implications for autoimmunity and immunotherapy
(Elsevier Science, 2019-04)
The immune system is responsible for defending the host from a large variety of potential pathogens, while simultaneously avoiding immune reactivity towards self-components. Self-tolerance has to be tightly maintained ...
Inverse relationship between alzheimer's disease and cancer: How immune checkpoints might explain the mechanisms underlying age-related diseases
(IOS Press, 2020)
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the adult population. There is evidence of an inverse epidemiological relationship between AD and cancer, another prevalent age-related disease. ...
The role of T-cells in head and neck squamous cell carcinoma: From immunity to immunotherapy.
(Frontiers Research Foundation, 2023)
Immune Checkpoint Inhibitor-Associated Pericarditis
(Elsevier Inc., 2019-06)
Side effects of immune checkpoint inhibitors, termed immune-related adverse events, are relatively common, but immune checkpoint inhibitor-mediated cardiotoxicities are rare; however, they can be serious and potentially ...