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Cytoplasmic and nuclear STAT3 in GH-stimulated fibroblasts of children with idiopathic short stature
(2010)
Background: STAT5, which plays an important role in GH signal transduction, has been studied extensively in children with growth retardation, but there is scarce information regarding STAT3. Aim: We determined total and ...
Ghrelin plasma levels in patients with idiopathic short stature
(2011)
Background: Novel molecular insights have suggested that ghrelin may be involved in the pathogenesis of some forms of short stature. Recently, growth hormone secretagogue receptor (GHSR) mutations that segregate with short ...
Growth hormone treatment in children with idiopathic short stature: correlation of growth response with peripheral thyroid hormone action
(Wiley Blackwell Publishing, Inc, 2011-03)
Idiopathic short stature (ISS) describes short children with normal GH secretion. Although GH treatment increases their heights, growth response to the therapy differs among patients. Thyroid hormones (TH) are essential ...
Expression of SOCS1, SOCS2, and SOCS3 in growth hormone-stimulated skin fibroblasts from children with idiopathic short stature
(2012)
Background/aim: Possible etiologies of idiopathic short stature (ISS) include a range of conditions, some of which may be caused by defects in the modulation of the growth hormone (GH)-signaling pathway. The Janus kinase/signal ...
Copy number variants in patients with short stature
(Nature Publishing Group, 2014)
Height is a highly heritable and classic polygenic trait. Recent genome-wide association studies (GWAS) have revealed that at least 180 genetic variants influence adult height. However, these variants explain only about ...
Expression of socs1, socs2, and socs3 in growth hormone-stimulated skin fibroblasts from children with idiopathic short stature
(FREUND PUBLISHING HOUSE, 2012)
An illustrative case of Leri-Weill dyschondrosteosis
(Soc Brasil GeneticaRibeirao PretBrasil, 2008)