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In Vitro Metabolism of Artepillin C by Rat and Human Liver Microsomes
(2017-05-01)
Artepillin C, a natural product present in the Brazilian green propolis, has several biological properties. Among these properties, the antitumor action of this product is noteworthy and makes it a promising drug candidate ...
Enantioselective in vitro metabolism and in vitro-in vivo correlation of the herbicide ethofumesate in a human model
(2020-08-05)
Ethofumesate (ETO) is a chiral herbicide that is marketed as a racemic mixture in the European Union and the United States. The growing consumption of pesticides in the world, along with their presence in water and food, ...
Macromolecular biosynthetic parameters and metabolic profile in different life stages of Leishmania braziliensis: Amastigotes as a functionally less active stage
(Public Library of Science, 2017)
It was recently hypothesized that Leishmania amastigotes could constitute a semi-quiescent stage characterized by low replication and reduced metabolic activity. This concept developed with Leishmania (Leishmania) mexicana ...
Carbon/nitrogen interactions during ear and kernel development of maize
(2015-10-26)
The interdependence of C and N metabolism in achieving maximum reproductive development of maize is well known, but poorly understood. Our experimental approach has been to use stem infusion and in vitro kernel culture to ...
In vitro basal and metabolism-mediated cytotoxicity of flavonoids
(Elsevier B.V., 2006-06-01)
The purpose of this study was to compare the basal cytotoxicity and metabolism-mediated cytotoxicity of kaempferol, quercetin and rutin. McCoy cells were exposed to various concentrations of the flavonols with and without ...
In vitro basal and metabolism-mediated cytotoxicity of flavonoids
(Elsevier B.V., 2006-06-01)
The purpose of this study was to compare the basal cytotoxicity and metabolism-mediated cytotoxicity of kaempferol, quercetin and rutin. McCoy cells were exposed to various concentrations of the flavonols with and without ...
In vitro-in vivo correlation of the chiral pesticide prothioconazole after interaction with human CYP450 enzymes
(2022-05-01)
Growing human demand for food has culminated in increased use of pesticides worldwide. Prothioconazole (PTC), a profungicide, is bioactivated by metabolic PTC oxidation to prothioconazole-desthio (D-PTC). Here, the in vitro ...
In vitro basal and metabolism-mediated cytotoxicity of flavonoids
(Elsevier B.V., 2014)
High concentrations of glucose reduce the oxidative metabolism of dog neutrophils in vitro
(2013-02-06)
Background: Dogs are commonly affected by hyperglycemic conditions. Hyperglycemia compromises the immune response and favors bacterial infections; however, reports on the effects of glucose on neutrophil oxidative metabolism ...
High concentrations of glucose reduce the oxidative metabolism of dog neutrophils in vitro
(2013-02-06)
Background: Dogs are commonly affected by hyperglycemic conditions. Hyperglycemia compromises the immune response and favors bacterial infections; however, reports on the effects of glucose on neutrophil oxidative metabolism ...