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Revisiting the role of TRP, orai, and ASIC channels in the pulmonary arterial response to hypoxia
(Frontiers Media S.A., 2018)
© 2018 Reyes, Castillo-Galán, Hernandez, Herrera, Ebensperger and Llanos. The pulmonary arteries are exquisitely responsive to oxygen changes. They rapidly and proportionally contract as arterial PO2 decrease, and they ...
Hypoxic pulmonary vasoconstriction in reptiles: a comparative study of four species with different lung structures and pulmonary blood pressures
(Amer Physiological Soc, 2005-11-01)
Low O-2 levels in the lungs of birds and mammals cause constriction of the pulmonary vasculature that elevates resistance to pulmonary blood flow and increases pulmonary blood pressure. This hypoxic pulmonary vasoconstriction ...
Hypoxic pulmonary vasoconstriction in reptiles: a comparative study of four species with different lung structures and pulmonary blood pressures
(Amer Physiological Soc, 2005-11-01)
Low O-2 levels in the lungs of birds and mammals cause constriction of the pulmonary vasculature that elevates resistance to pulmonary blood flow and increases pulmonary blood pressure. This hypoxic pulmonary vasoconstriction ...
Hypoxic pulmonary vasoconstriction and ambient temperature
(Springer-Verlag, 1982)
Long-term exposure to high-altitude chronic hypoxia during gestation induces neonatal pulmonary hypertension at sea level
(2010)
We determined whether postnatal pulmonary hypertension induced by 70% of pregnancy at high altitude (HA) persists once the offspring return to sea level and investigated pulmonary vascular mechanisms operating under these ...
Melatonin decreases pulmonary vascular remodeling and oxygen sensitivity in pulmonary hypertensive newborn lambs
(Frontiers media SA, 2018)
Background: Chronic hypoxia and oxidative stress during gestation lead to pulmonary hypertension of the neonate (PHN), a condition characterized by abnormal pulmonary arterial reactivity and remodeling. Melatonin has strong ...
Store-operated channels in the pulmonary circulation of high- and low-altitude neonatal lambs
(American Physiological Society, 2013)
We determined whether store-operated channels (SOC) are involved in neonatal pulmonary artery function under conditions of acute and chronic hypoxia, using newborn sheep gestated and born either at high altitude (HA, 3,600 ...
Melatonin reduces oxidative stress and improves vascular function in pulmonary hypertensive newborn sheep
(Wiley, 2015)
Pulmonary hypertension of the newborn (PHN) constitutes a critical condition with severe cardiovascular and neurological consequences. One of its main causes is hypoxia during gestation, and thus, it is a public health ...
Global Research Expedition on Altitude-related Chronic Health 2018 Iron Infusion at High Altitude Reduces Hypoxic Pulmonary Vasoconstriction Equally in Both Lowlanders and Healthy Andean Highlanders
(Elsevier, 2022)
Background: Increasing iron bioavailability attenuates hypoxic pulmonary vasoconstriction in both lowlanders and Sherpas at high altitude. In contrast, the pulmonary vasculature of Andean individuals with chronic mountain ...