Search
Now showing items 1-10 of 12
Neuroinflammation in Huntington’s Disease: A Starring Role for Astro-cyte and Microglia
(Bentham Science Publishers, 2021-11-26)
Huntington’s disease (HD) is a neurodegenerative genetic disorder caused by a CAG repeat expansion in the huntingtin gene. HD causes motor, cognitive, and behavioral dysfunction. Since no existing treatment affects the ...
Losing ground: Frontostriatal atrophy disrupts language embodiment in Parkinson's and Huntington's disease
(Pergamon-Elsevier Science Ltd, 2017-09)
Within the language domain, movement disorders triggered by frontostriatal damage are characterized by deficits in action verbs, motor-language coupling, and syntax. However, these impairments have not been jointly interpreted ...
Clinical and genetic characteristics in patients with Huntington's Disease from Argentina
(Elsevier, 2012-02)
Huntington's Disease (HD) is a neurodegenerative disease, caused by the expansion of an unstable (CAG) n in the HTT gene. There is scarce data about the disease in Argentina. Objective: To describe the demographic, clinical ...
Impairments in negative emotion recognition and empathy for pain in Huntington's disease families
(Pergamon-Elsevier Science Ltd, 2015-02)
Lack of empathy and emotional disturbances are prominent clinical features of Huntington's disease (HD). While emotion recognition impairments in HD patients are well established, there are no experimental designs assessing ...
Your misery is no longer my pleasure: Reduced schadenfreude in Huntington's disease families
(Elsevier Masson, 2016-10)
Schadenfreude – pleasure at others' misfortunes – has been systematically related to ventral striatum activity. This brain region is affected early in individuals with manifest and pre-manifest Huntington's disease (HD). ...
Heart rate variability and falls in Huntington’s disease
(Dr. Dietrich Steinkopff Verlag, 2020-02)
Purpose: Persons with Huntington's disease (HD) have a high incidence of falls. Autonomic nervous system dysfunction has been reported even in early stages of this disease. To date, there has been no analysis of the ...
How have advances in genetic technology modified movement disorder nosology?
(Wiley Blackwell Publishing, Inc, 2020-04)
The role of genetics and its technological development have been fundamental in advancing the field of movement disorders, opening the door to precision medicine. Starting from the revolutionary discovery of the locus of ...
Astrocytes from cortex and striatum show differential responses to mitochondrial toxin and BDNF: Implications for protection of striatal neurons expressing mutant huntingtin
(BioMed Central, 2020-10)
Background: Evidence shows significant heterogeneity in astrocyte gene expression and function. We previously demonstrated that brain-derived neurotrophic factor (BDNF) exerts protective effects on whole brain primary ...
24S‐hydroxycholesterol: cellular effects and variations in brain diseases
(Wiley Blackwell Publishing, Inc, 2020-05)
The adult brain exhibit a characteristic cholesterol homeostasis, with low synthesis rate and active catabolism. Brain cholesterol turnover is possible thanks to the action of the enzyme Cytochrome P450 46A1 (CYP46A1) or ...
Participation of Rabs during Neuronal Development and Disease
(OMICS International, 2019)
Membrane traffic has been widely studied in recent decades, and now it is clear that its participation in biologicalprocesses such as cellular migration, mitosis, and immune response, among others, is crucial and ...