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Humanin, a mitochondrial-derived peptide released by astrocytes, prevents synapse loss in hippocampal neurons
(Frontiers Media SA, 2019-05)
Astroglial cells are crucial for central nervous system (CNS) homeostasis. They undergo complex morpho-functional changes during aging and in response to hormonal milieu. Ovarian hormones positively affect different astroglia ...
Antiapoptotic factor humanin is expressed in normal and tumoral pituitary cells and protects them from TNF-α-induced apoptosis
(Public Library Of Science, 2014-10)
Humanin (HN) is a 24-amino acid peptide with cytoprotective action in several cell types such as neurons and testicular germ cells. Rattin (HNr), a homologous peptide of HN expressed in several adult rat tissues, also has ...
Humanin promotes tumor progression in experimental triple negative breast cancer
(Nature Publishing Group, 2020-12)
Humanin (HN) is a mitochondrial-derived peptide with cytoprotective effect in many tissues. Administration of HN analogs has been proposed as therapeutic approach for degenerative diseases. Although HN has been shown to ...
Mitochondrial-derived peptide humanin as therapeutic target in cancer and degenerative diseases
(Informa Healthcare, 2019-02)
Introduction: Mitochondrial-derived peptides (MDPs) are encoded within the mitochondrial genome. They signal within the cell or are released to act as autocrine/paracrine/endocrine cytoprotective factors playing a key role ...
Baculovirus-based gene silencing of Humanin for the treatment of pituitary tumors
(Springer, 2018-02)
Pituitary tumors are the most common primary intracranial neoplasms. Humanin (HN) and Rattin (HNr), a rat homolog of HN, are short peptides with a cytoprotective action. In the present study, we aimed to evaluate whether ...