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Hereditary hemochromatosis: An opportunity for gene therapy
(SOCIEDAD BIOLGIA CHILE, 2006)
Levels of body iron should be tightly controlled to prevent the formation of oxygen radicals. lipoperoxidation. genotoxicity, and the production of cytotoxic cytokines, which result in damage to a number of organs. Enterocytes ...
Apical distribution of HFE-β2-microglobulin is associated with inhibition of apical iron uptake in intestinal epithelia cells
(2006)
Mutations in the HFE gene result in hereditary hemochromatosis, a disorder of iron metabolism characterized by increased intestinal iron absorption. Based on the observation that ectopic expression of HFE strongly inhibits ...
Antisense gene delivered by an adenoassociated viral vector inhibits iron uptake in human intestinal cells: Potential application in hemochromatosis
(PERGAMON-ELSEVIER SCIENCE LTD, 2005-06-01)
Hereditary hemochromatosis (HH) is a condition in which intestinal iron absorption is greatly elevated. Present treatment is weekly phlebotomy, affecting quality of life and leading to recurrent infections. The iron ...