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The modulatory effect of triclosan on the reversion of the activated phenotype of LX-2 hepatic stellate cells
(Wiley-Blackwell, 2019-11-12)
Hepatic diseases leading to fibrosis affect millions of individuals worldwide and are a major public health challenge. Although, there have been many advances in understanding hepatic fibrogenesis, an effective therapy ...
Influence of antiretroviral therapy on bone metabolism of patients with chronic hepatitis B: a review
(Soc Brasileira Medicina Tropical, 2019-01-01)
Hepatitis B is a major public health problem worldwide and associated with significant mortality. To prevent or delay the deleterious effects of chronic infection by the hepatitis B virus, patients should be carefully ...
CYP450 Metabolism of a Semisynthetic Naphthoquinone, an Anticancer Drug Candidate, by Human Liver Microsomes
(Soc Brasileira Quimica, 2022-02-21)
CNFD (6b,7-dihydro-5H-cyclopenta[b]naphtho[2,1-d]furan-5,6(9aH)-dione) is a semisynthetic naphthoquinone derived from lawsone that has cytotoxic action in different tumor lines and anticancer activity in vivo. Therefore, ...
Factors influencing hepatic metabolism of antihypertensive drugs: impact on clinical response
(Informa Healthcare, 2019-01)
Introduction: Although main antihypertensive drugs are able to efficiently reduce blood pressure, only a third of treated hypertensive patients achieve optimal blood pressure control. Extensive interpatient variability on ...
Neonatal rat exposure to pyrethroid and organophosphate insecticides: A physiological and biochemical trial of progeny
(2004-10-14)
A manufactured product (Ectoplus®) composed by a cypermethrin (44.7%) and dichlorvos (4.2%) mixture was administered (10mg/kg/day, orally, by gavage) to pregnant rats, during the periods of gestation+lactation, gestation, ...
Neonatal rat exposure to pyrethroid and organophosphate insecticides: A physiological and biochemical trial of progeny
(2004-10-14)
A manufactured product (Ectoplus®) composed by a cypermethrin (44.7%) and dichlorvos (4.2%) mixture was administered (10mg/kg/day, orally, by gavage) to pregnant rats, during the periods of gestation+lactation, gestation, ...
Toxicity of hypercaloric diet and monosodium glutamate: oxidative stress and metabolic shifting in hepatic tissue.
(2004-02-01)
The present study examines the effects of a hypercaloric diet on hepatic glucose metabolism of young rats, with and without monosodium glutamate (MSG) administration, and the association of these treatments with evaluating ...
Toxicity of hypercaloric diet and monosodium glutamate: oxidative stress and metabolic shifting in hepatic tissue.
(2004-02-01)
The present study examines the effects of a hypercaloric diet on hepatic glucose metabolism of young rats, with and without monosodium glutamate (MSG) administration, and the association of these treatments with evaluating ...