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HNSCC subverts PBMCs to secrete soluble products that promote tumor cell proliferation
(Impact Journals Llc, 2017-09-05)
The immune system detects shifts from homeostasis and eliminates altered cells. However, neoplastic cells can modulate the host response to escape immunosurveillance thereby allowing tumor progression. Head and neck squamous ...
TIMP3 and CCNA1 hypermethylation in HNSCC is associated with an increased incidence of second primary tumors
(Biomed Central Ltd, 2013-12-20)
Background: Hypermethylation in the promoter regions is associated with the suppression of gene expression and has been considered a potential molecular marker for several tumor types, including head and neck squamous cell ...
Loss of Expression and Function of SOCS3 Is an Early Event in HNSCC: Altered Subcellular Localization as a Possible Mechanism Involved in Proliferation, Migration and Invasion
(Public Library Science, 2012-09-18)
Background: Suppressor of cytokine signaling 3 (SOCS3) is an inducible endogenous negative regulator of signal transduction and activator of transcription 3 (STAT3). Epigenetic silencing of SOCS3 has been shown in head and ...
Loss of Expression and Function of SOCS3 Is an Early Event in HNSCC: Altered Subcellular Localization as a Possible Mechanism Involved in Proliferation, Migration and Invasion
(Public Library Science, 2012-09-18)
Background: Suppressor of cytokine signaling 3 (SOCS3) is an inducible endogenous negative regulator of signal transduction and activator of transcription 3 (STAT3). Epigenetic silencing of SOCS3 has been shown in head and ...
SET protein accumulates in HNSCC and contributes to cell survival: Antioxidant defense, Akt phosphorylation and AVOs acidification
(ELSEVIER SCIENCE BVAMSTERDAM, 2012)
Objectives: Determination of the SET protein levels in head and neck squamous cell carcinoma (HNSCC) tissue samples and the SET role in cell survival and response to oxidative stress in HNSCC cell lineages. Materials and ...
Unraveling the oral cancer lncRNAome: Identification of novel lncRNAs associated with malignant progression and HPV infection
(Elsevier Science, 2016-08)
SummaryObjectives The role of long non-coding RNA (lncRNA) expression in human head and neck squamous cell carcinoma (HNSCC) is still poorly understood. In this study, we aimed at establishing the onco-lncRNAome profiling ...
Modulação da imunidade adaptativa por produtos solúveis de células de carcinoma espinoceular de cabeça e pescoço (HNSCC): um papel da galanina derivada do tumor?
(Universidade Estadual Paulista (Unesp), 2016-03-31)
Carcinoma espinocelular de cabeça e pescoço (HNSCC, squamous cell carcinoma of the head and neck) é uma neoplasia caracterizada mais comumente por invasão local/regional de prognóstico sombrio quando diagnosticada em ...