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Design, synthesis, and docking of highly hypolipidemic agents: Schizosaccharomyces pombe as a new model for evaluating a-asarone-based HMG-CoA reductase inhibitors
(2013-01-30)
A series of a-asarone-based analogues was designed by conducting docking experiments with published
crystal structures of human HMG-CoA reductase. Indeed, synthesis and evaluation of this series showed a
highly ...
Design, synthesis, and docking of highly hypolipidemic agents:Schizosaccharomyces pombe as a new model for evaluating a-asarone-based HMG-CoA reductase inhibitors
(2013-02-26)
A series of a-asarone-based analogues was designed by conducting docking experiments with published
crystal structures of human HMG-CoA reductase. Indeed, synthesis and evaluation of this series showed a
highly ...
IAF, QGF, and QDF peptides exhibit cholesterol-lowering activity through a statin-like HMG-CoA reductase regulation mechanism: In silico and in vitro approach
(2021-10-01)
In this study, in silico approaches are employed to investigate the binding mechanism of peptides derived from cowpea β-vignin and HMG-CoA reductase. With the obtained information, we designed synthetic peptides to evaluate ...
Policosanol modula la actividad de HMG-CoA reductasa en fibroblastos cultivados
(2001)
La biosíntesis de colesterol es estrictamente controlada por la 3-hidroxi-3-metilglutaril Coenzima A (HMG-CoA) reductasa. La transferencia de fibroblastos cultivados a un medio agotado en lípidos (LDM) regula los niveles ...
In vitro and in silico studies of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitory activity of the cowpea Gln-Asp-Phe peptide
(2018-09-01)
Previous studies have shown that cowpea protein positively interferes with cholesterol metabolism. In this study, we evaluated the ability of the fraction containing peptides of <3 kDa, as well as that of the Gln-Asp-Phe ...
Design, synthesis, and docking of highly hypolipidemic agents: Schizosaccharomyces pombe as a new model for evaluating a-asarone-based HMG-CoA reductase inhibitors
(2012-11-28)
A series of a-asarone-based analogues was designed by conducting docking experiments with published
crystal structures of human HMG-CoA reductase. Indeed, synthesis and evaluation of this series showed a
highly ...
Processo de conversão de substrato renovável por aspergillus terreus UCP 0076 na biossíntese do inibidor da HMG-CoA redutase e intermediários.
(Universidade Católica de Pernambuco, 2021-03-08)
HMG-CoA reductase (3-hydroxy-3-methylglutaryl-coenzyme reductase) is the enzyme
that has a limiting role in cholesterol biosynthesis. Among the HMG-CoA reductase
inhibitory molecules, statins stand out, such as simvastatin, ...