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Investigação dos imunomoduladores produzidos por astrócitos derivados de células-tronco de pluripotência induzida (hIPSCs) de pacientes com esquizofrenia
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIAPrograma de Pós-Graduação em Bioquímica e ImunologiaUFMG, 2018-02-21)
Schizophrenia is a psychiatric disorder, caused by a conjunction of genetic,
environmental and developmental factors. Individuals bearing this disease exhibit
cognitive deficits, positive (psychosis, hallucinations and ...
Alteraciones en el nicho neurovascular durante el desarrollo del cerebro esquizofrénico
(Universidad de Chile, 2020)
La formación de vasos sanguíneos en el cerebro ocurre de manera simultánea a la formación de neuronas y glías durante el desarrollo embrionario, generándose el nicho neurovascular. Las señales presentes en este nicho son ...
Altered resting-state functional connectivity in hiPSCs-derived neuronal networks from schizophrenia patients
(Frontiers Media, 2022)
Schizophrenia (SZ) is a severe mental disorder that arises from abnormal neurodevelopment, caused by genetic and environmental factors. SZ often involves distortions in reality perception and it is widely associated with ...
The Histone Demethylase JMJD2A Modulates the Induction of Hypertrophy Markers in iPSC-Derived Cardiomyocytes
(Frontiers in Genetics, 2018-02-09)
The development of cardiovascular pathologies is partly attributed to epigenetic causes, including histone methylation, which appears to be an important marker in hearts that develop cardiac hypertrophy. Previous studies ...
Schizophrenia-derived hiPSC brain microvascular endothelial-like cells show impairments in angiogenesis and blood–brain barrier function
(2022)
Schizophrenia (SZ) is a complex neuropsychiatric disorder, affecting 1% of the world population. Long-standing clinical observations and molecular data have pointed to a possible vascular deficiency that could be acting ...
Regulation of cyclin E1 expression in human pluripotent stem cells and derived neural progeny
(Landes Bioscience, 2018-07)
Human pluripotent stem cells (hPSCs), including embryonic and induced pluripotent stem cells (hESCs and hiPSCs) show unique cell cycle characteristics, such as a short doubling time due to an abbreviated G1 phase. Whether ...
hiPSC derived neural stem cells from patients with schizophrenia induce an impaired angiogenesis
(Nature Publishing Group, 2018)
Schizophrenia is a neurodevelopmental disease characterized by cerebral connectivity impairment and loss of gray matter. It was described in adult schizophrenia patients (SZP) that concentration of VEGFA, a master angiogenic ...
Avaliação do tratamento com VU0409551 em astrócitos derivados de hiPSCs estimulados com citocinas pró-inflamatórias associadas à Esclerose Múltipla
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIACurso de Especialização em Bioquímica e ImunologiaUFMG, 2022-07-21)
Multiple sclerosis (MS) is a neuroinflammatory, autoimmune, chronic and disabling
disease that affects the central nervous system due to an autoimmune response
against myelin proteins, along with the formation of ...
Desenvolvimento e caracterização de córneas humanas descelularizadas e recelularização com células-tronco visando regeneração do epitélio corneano anterior
(Universidade Federal de Minas GeraisBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASPrograma de Pós-Graduação em Biologia CelularUFMG, 2017-07-25)
Numerous diseases can affect corneal structure, leading to visual impairment and even
blindness. Currently, the only treatment for most corneal illnesses is transplantation of corneal
allografts. However, graft rejection ...
Characterization of the epidermal-dermal junction in hiPSC-derived skin organoids
(2022)
Human induced pluripotent stem cell (hiPSC)-derived hair-bearing skin organoids offer exciting new possibilities for modeling diseases like epidermolysis bullosa (EB). These inherited diseases affect 1 in 30,000 people ...