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14-Helical folding in a cyclobutane-containing β-tetrapeptide
(American Chemical Society, 2004-08)
The efficient synthesis of tetrapeptide 5 containing, in alternation, cyclobutane and β-alanine residues is described. NMR experiments both at low temperature in CDCl3 and at 298 K in DMSO-d6 solutions show the contribution ...
Rational design of antiangiogenic helical oligopeptides targeting the vascular endothelial growth factor receptors
(Frontiers Media S.A., 2019-03)
Tumor angiogenesis, essential for cancer development, is regulated mainly by vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs), which are overexpressed in cancer cells. Therefore, the VEGF/VEGFR ...
14-helical folding in a cyclobutane-containing beta-tetrapeptide
(AMER CHEMICAL SOC, 2004-07-23)
The efficient synthesis of tetrapeptide 5 containing, in alternation, cyclobutane and beta-alanine residues is described. NMR experiments both at low temperature in CDCl3 and at 298 K in DMSOd(6) solutions show the ...
Thioredoxin from Escherichia coli as a role model of molecular recognition, folding, dynamics and function
(Bentham Science Publishers, 2015-09)
Thioredoxin (TRX) catalyzes redox reactions via the reversible oxidation of the conserved active center CGPC and it is involved in multiple biological processes, some of them linked to redox activity while others not. TRX ...
Strategies for exploring electrostatic and nonelectrostatic contributions to the interaction of helical antimicrobial peptides with model membranes
(2016-01-01)
Linear antimicrobial peptides, short sequences up to 50 amino acids, rich in basic and hydrophobic residues, are able to form an amphipathic helix when adsorbed onto lipid membranes. Thanks to these characteristics they ...
Self-association and folding in membrane determine the mode of action of peptides from the lytic segment of sticholysins
(Elsevier B.V., 2019-01-01)
Sticholysin I and II (Sts: St I and St II) are proteins of biomedical interest that form pores upon the insertion of their N-terminus in the plasma membrane. Peptides spanning the N-terminal residues of StI (StI(1-31)) or ...
Structural selection of a native fold by peptide recognition. Insights into the thioredoxin folding mechanism
(American Chemical Society, 2009-01)
Thioredoxins (TRXs) are monomeric alpha/beta proteins with a fold characterized by a central twisted beta-sheet surrounded by alpha-helical elements. The interaction of the C-terminal alpha-helix 5 of TRX against the ...
The role of the N-terminal tail for the oligomerization, folding and stability of human frataxin
(Elsevier, 2013-07)
The N-terminal stretch of human frataxin (hFXN) intermediate (residues 42?80) is not conserved throughout evolution and, under defined experimental conditions, behaves as a random-coil. Overexpression of hFXN56?210 in E. ...
How reliable could economic Hartree-Fock computations be in studying large, folded peptides? A comparative HF and DFT case study on N- and C-protected aspartic acid
(Elsevier Science, 2002-12)
In this study, potential energy hypersurfaces have been generated and analyzed for each of the nine possible backbone (BB) conformations for both the endo and exo forms of N-acetyl-L-aspartic acid N′-methylamide. Ab initio ...
How C-terminal carboxyamidation alters the biological activity of peptides from the venom of the eumenine solitary wasp
(Amer Chemical Soc, 2004-05-18)
Inflammatory peptides display different types of post-transcriptional modifications, such as C-terminal amidation, that alter their biological activity. Here we describe the structural and molecular dynamics features of ...