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Structural analysis of effector functions related motifs, complement activation and hemagglutinating activities in Lama glama heavy chain antibodies
(Elsevier Science, 2012-01)
Heavy chain antibodies (HCAbs), devoid of the light chains and the CH 1 domain, are present in the serum of camelids. IgG 2 and IgG 3 are HCAbs; whereas IgG 1 has the conventional structure. In order to study the immunological ...
Heavy Chain Antibodies: The panacea for human health or just incomplete proteins?
(Research Trends, 2013-06)
Since 1993, Heavy Chain Antibodies (HCAbs) have been in the eye of a biotechnological storm. Ever since their discovery, several research groups as well as biomedical foundations and pharmaceutical companies have devoted ...
Caracterización de IgM, IgG total, IgG1 y anticuerpos de cadena pesada en calostro de llamas (Lama Glama) mediante ElisaCharacterization of IgM, total IgG, igG1 and hcabs in colostra of llamas (Lama glama) by Elisa
(Universidad Complutense de Madrid, 2014-10)
Objetivos: determinar los niveles de IgM, IgG total y Anticuerpos de Cadena Pesada (HCAbs; por su sigla en inglés Heavy Chain Antibodies) (IgG2 e IgG3) en calostro de llamas y evaluar la concentración de HCAbs en relación ...
Avaliação da dinâmica estrutural do domínio variável de anticorpos de cadeia pesada única derivados de camelídeos (VHH)
(Pós-Graduação em QuímicaUniversidade Federal de Sergipe (UFS), 2023)
Single domain antibodies: Promising experimental and therapeutic tools in infection and immunity
(Springer, 2009-08)
Antibodies are important tools for experimental research and medical applications. Most antibodies are composed of two heavy and two light chains. Both chains contribute to the antigen-binding site which is usually flat ...
Molecular evolution of broadly neutralizing llama antibodies to the CD4-binding site of HIV-1
(Public Library of Science, 2014-12)
To date, no immunization of humans or animals has elicited broadly neutralizing sera able to prevent HIV-1 transmission; however, elicitation of broad and potent heavy chain only antibodies (HCAb) has previously been ...
State of the Art on Plant-Made Single-Domain Antibodies
(SciTechnol, 2014-08)
In addition to conventional antibodies (with heavy and light chains), camelids also produce functional antibodies devoid of light chains (HCAbs) without the first constant domain (CH1). Their variable domains (VHH) have ...
Generación de anticuerpos de dominio único específicos para CD105 humano
(Universidad Peruana Cayetano HerediaPE, 2016)
Los anticuerpos de dominio único o anticuerpos de cadena pesada (HCAbs por sus siglas en inglés Heavy Chain antibodies) son inmunoglobulinas de tipo G que carecen de cadena ligera. Existe un gran interés por la región ...