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Phosphorylation of Histone H3S10 in Animal Chromosomes: Is There a Uniform Pattern?
Phosphorylation of serine 10 in histone H3 (H3S10ph) has been extensively analyzed and appears to be a conserved chromatin change associated with chromosome condensation in different eukaryotic organisms. In this work, we ...
Membrane actions of male contraceptive gossypol tautomers
The role of different gossypol tautomers in the interaction of this molecule with membranes has been investigated using the isolated hemiacetal moiety of gossypol and the pH dependency of the keto-enol tautomeric equilibrium. ...
Chemical dissection of the APC repeat 3 multistep phosphorylation by the concerted action of protein kinases CK1 and GSK3
A crucial event in machinery controlled by Wnt signaling is the association of β-catenin with the adenomatous polyposis coli (APC) protein, which is essential for the degradation of β-catenin and requires the multiple ...
Synthesis, characterization and evaluation of phosphorylated resins in the removal of Pb(2+) from aqueous solutions
Phosphinic-derivative poly(styrene-co-divinylbenzene)-based on PS-DVB copolymers with different porosity degrees have been prepared by aromatic electrophilic substitution reaction using PCl(3)/AlCl(3) followed by base-promoted ...
Calcium release by ryanodine receptors mediates hydrogen peroxide-induced activation of ERK and CREB phosphorylation in N2a cells and hippocampal neurons
Hydrogen peroxide, which stimulates ERK phosphorylation and synaptic plasticity in hippocampal neurons, has also been shown to stimulate calcium release in muscle cells by promoting ryanodine receptor redox modification ...
Chk1 phosphorylation of Metnase enhances DNA repair but inhibits replication fork restart
(NATURE PUBLISHING GROUPLONDON, 2012)
Chk1 both arrests replication forks and enhances repair of DNA damage by phosphorylating downstream effectors. Although there has been a concerted effort to identify effectors of Chk1 activity, underlying mechanisms of ...