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Grandisin caused morphological changes larval and toxicity on Aedes aegypti
(Sociedade Brasileira de Farmacognosia, 2017)
Cytotoxicity and antiangiogenic activity of grandisin
(WILEY-BLACKWELL PUBLISHING, INC, 2009)
Objectives The antitumoural properties of grandisin, a tetrahydrofuran neolignan from Piper solmsianum, were investigated by in-vitro and in-vivo assays using the Ehrlich ascites tumoural (EAT) model. Methods Viability of ...
Chemoprotective effect of the tetrahydrofuran lignan grandisin in the in-vivo rodent micronucleus assay
(WILEY-BLACKWELL, 2011)
Objectives The chemoprotective effect of the tetrahydrofuran lignan grandisin against DNA damage induced by cyclophosphamide (200 mg/kg) has been evaluated using the in vitro rodent micronucleus assay. Methods The effects ...
Disruption of Chrysomya megacephala Growth Caused by Lignan Grandisin
(ENTOMOLOGICAL SOC AMER, 2009)
The toxicity of tetrahydrofuran lignan grandisin was evaluated against larvae of Chrysomya megacephala F. (Diptera: Calliphoridae). The bioassay involved topical treatment on larvae, topical treatment oil egg masses, and ...
Disruption of Chrysomya megacephala Growth Caused by Lignan Grandisin
(Oxford University Press, 2019)
Antinociceptive and Antiinflammatory Activities of Grandisin extracted from Virola surinamensis
(Wiley-Blackwell, 2010-01-01)
The antinociceptive and antiinflammatory properties of the neolignan, grandisin, isolated from Virola surinamensis (Myristicaceae) were investigated. Grandisin (GRA) is present in several plant species from Brazil used in ...
In vitro basal cytotoxicity assay applied to estimate acute oral systemic toxicity of grandisin and its major metabolite
(ELSEVIER GMBH, URBAN & FISCHER VERLAG, 2011)
Preclinical investigations can start with preliminary in vitro studies before using animal models. Following this approach, the number of animals used in preclinical acute toxicity testing can be reduced. In this study, ...
In vitro Metabolism of Grandisin, a Lignan with Anti-chagasic Activity
(GEORG THIEME VERLAG KGSTUTTGART, 2012-12)
Tetrahydrofuran lignans represent a well-known group of phenolic compounds capable of acting as antiparasitic agents. In the search for new medicines for the treatment of Chagas disease, one promising compound is grandisin ...
Grandisin caused morphological changes larval and toxicity on Aedes aegypti
(Sociedade Brasileira de Farmacognosia, 2012)
Dengue is a tropical disease caused by an arbovirus transmitted by Aedes aegypti. Since no effective vaccine is available for treating dengue, the present study focused on population vector control through investigating ...
Larvicidal activity of grandisin against Aedes aegypti
(American Mosquito Control Association, 2019)