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Gomesin, a peptide produced by the spider Acanthoscurria gomesiana, is a potent anticryptococcal agent that acts in synergism with fluconazole
(Blackwell Publishing, 2007-09-01)
Gomesin is an 18-residue cysteine-rich antimicrobial peptide produced by hemocytes of the spider Acanthoscurria gomesiana. in the present study, the antifungal properties of gomesin against Cryptococcus neoformans, the ...
Peptide gomesin triggers cell death through L-type channel calcium influx, MAPK/ERK, PKC and PI3K signaling and generation of reactive oxygen species
(ELSEVIER IRELAND LTD, 2010)
Gomesin is an antimicrobial peptide isolated from hemocytes of a common Brazilian tarantula spider named Acanthoscurriagomesiana. This peptide exerts antitumor activity in vitro and in vivo by an unknown mechanism. In this ...
Effect of the antimicrobial peptide gomesin against different life stages of Plasmodium spp.
(Elsevier B.V., 2007-08-01)
While seeking strategies for interfering with Plasmodium development in vertebrate/invertebrate hosts, we tested the activity of gomesin, an antimicrobial peptide isolated from the hemocytes of the spider Acanthoscurria ...
The role of disulfide bridges in the 3-D structures of the antimicrobial peptides gomesin and protegrin-1: a molecular dynamics study
(FUNPEC-EDITORA, 2008)
Some antimicrobial peptides have a broad spectrum of action against many different kinds of microorganisms. Gomesin and protegrin-1 are examples of such antimicrobial peptides, and they were studied by molecular dynamics ...
Therapeutic use of a cationic antimicrobial peptide from the spider Acanthoscurria gomesiana in the control of experimental candidiasis
(BIOMED CENTRAL LTDLONDON, 2012)
Background: Antimicrobial peptides are present in animals, plants and microorganisms and play a fundamental role in the innate immune response. Gomesin is a cationic antimicrobial peptide purified from haemocytes of the ...
Therapeutic use of a cationic antimicrobial peptide from the spider Acanthoscurria gomesiana in the control of experimental candidiasis
(BMC, 2012-03-06)
Background
Antimicrobial peptides are present in animals, plants and microorganisms and play a fundamental role in the innate immune response. Gomesin is a cationic antimicrobial peptide purified from ...
Therapeutic use of a cationic antimicrobial peptide from the spider Acanthoscurria gomesiana in the control of experimental candidiasis
(2012-03-06)
Abstract
Background
Antimicrobial peptides are present in animals, plants and microorganisms and play a fundamental role in the innate immune response. Gomesin is a cationic ...
Structure-activity relationship of Trp-containing analogs of the antimicrobial peptide gomesin
(Wiley-Blackwell, 2014-06-01)
Gomesin (Gm) has a broad antimicrobial activity making it of great interest for development of drugs. in this study, we analyzed three Gm analogs, [Trp(1)]-Gm, [Trp(7)]-Gm, and [Trp(9)]-Gm, in an attempt to gain insight ...