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Evidence for different gonadotropin-releasing hormone response sites in rat ovarian and pituitary cells
(Society for the Study of Reproduction, 2004-12)
The participation of type I GnRH receptor (GnRH-R) on GnRH-II-induced gonadotropin secretion in rat pituitary cells was investigated. Furthermore, we extended the study of GnRH-II action to ovarian cells. The GnRH-II was ...
Gonadotropin releasing hormone analogs induce apoptosis by extrinsic pathway involving p53 phosphorylation in primary cell cultures of human prostatic adenocarcinomas
(Wiley, 2009)
BACKGROUND. Gonadotropin-releasing-hormone (GnRH) analogs are widely used to block
hypothalamic–pituitary–gonadal axis and inhibit blood androgen levels in patients with
prostate cancer (PCa). In addition, GnRH analogs ...
Agonistas do GnRH, antagonistas do GnRH e a reprodução assistida: Análogos do GnRH x fertilização in vitro
(2012-09-10)
The agonists of gonadotropin-releasing hormone (GnRH) were introduced in ovarian stimulation for in vitro fertilization to avoid a premature surge of luteinizing hormone. Although they are accompanied by some disadvantages, ...
Agonistas do GnRH, antagonistas do GnRH e a reprodução assistida: Análogos do GnRH x fertilização in vitro
(2012-09-10)
The agonists of gonadotropin-releasing hormone (GnRH) were introduced in ovarian stimulation for in vitro fertilization to avoid a premature surge of luteinizing hormone. Although they are accompanied by some disadvantages, ...
Effect of GnRH analogs in postnatal domestic cats
(Elsevier Science Inc, 2014-07)
The aim of this study was to reproductively assess the clinical and hormonal effects of a GnRH agonist (AG) and an antagonist (AN) administered during the postnatal period in domestic cats. Forty-eight male and female ...
GnRH analog is ineffective in increasing adult height in girls with puberty onset after 7 years of age: A systematic review and meta-analysis
(2018-12-01)
Objective: We assessed the effectiveness of puberty blockade with a gonadotropin-releasing hormone (GnRH) analog in increasing adult height (AH) in girls with puberty onset between 7 and 10 years of age. Methods: We performed ...
Effect of GnRH analogs on the expression of TrkA and p75 neurotrophin receptors in primary cell cultures from human prostate adenocarcinoma
(WILEY-LISS, DIV JOHN WILEY & SONS INC, 2005-11-01)
BACKGROUND. GnRH analogs have antiproliferative and/or apoptotic effects on prostate cancer cells. Also, neurotrophin receptors TrkA and p75 have been reported in normal prostate suggesting a role in the gland growth ...
Regulation of ovarian angiogenesis and apoptosis by GnRH-analogs
(Wiley, 2008)
An adequate vascular supply is important to provide endocrine and paracrine signals during follicular development. We evaluated the direct in vivo effects of both the GnRH-agonist Leuprolide acetate (LA) and the GnRH-antagonist ...