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Molecular mechanisms underlying glutamatergic dysfunction in schizophrenia: Therapeutic implications
(2009)
Early models for the etiology of schizophrenia focused on dopamine neurotransmission because of the powerful anti-psychotic action of dopamine antagonists. Nevertheless, recent evidence increasingly supports a primarily ...
From glutamatergic dysfunction to cognitive impairment: Boundaries in the therapeutic of the schizophrenia
(Bentham Science, 2012)
Cognitive deficits are trait markers in schizophrenia and the improvement of these dysfunctions has been considered as a new frontier of treatment in this disease. A current model for the patophysiology of schizophrenia ...
Effects of 3 weeks GMP oral administration on glutamatergic parameters in mice neocortex
(SPRINGERDORDRECHT, 2012)
Overstimulation of the glutamatergic system (excitotoxicity) is involved in various acute and chronic brain diseases. Several studies support the hypothesis that guanosine-5'-monophosphate (GMP) can modulate glutamatergic ...
Expressão de GABA e plasticidade do fenótipo neuroquímico e morfológico de células da Zona Subventricular pós-natal
(Brasil, 2008)
The subventricular zone (SVZ) is proliferative epithelium that continuously gives rise to new neurons in postnatal and adult mammals. The neurons generated in the SVZ migrate through the rostral migratory stream (RMS) where ...
Cholinergic and glutamatergic agonists induce gamma frequency activity in dorsal subcoeruleus nucleus neurons
(American Physiological Society, 2011-05)
The dorsal subcoeruleus nucleus (SubCD) is involved in generating two signs of rapid eye movement (REM) sleep: muscle atonia and ponto-geniculo-occipital (PGO) waves. We tested the hypothesis that single cell and/or ...
Avaliação da neurotransmissão glutamatérgica no núcleo do trato solitário de ratos submetidos à desnutrição proteica perinatal
(Universidade Federal de PernambucoUFPEBrasilPrograma de Pos Graduacao em Nutricao, Atividade Fisica e Plasticidade Fenotipica, 2018)
The role of nicotinic cholinergic neurotransmission in delusional thinking
(Nature Publishing Group, 2020-12)
Delusions are a difficult-to-treat and intellectually fascinating aspect of many psychiatric illnesses. Although scientific progress on this complex topic has been challenging, some recent advances focus on dysfunction in ...
Role of galectin-8 and dysfunctions by autoantibodies in the brain
(2021)
Galectin-8 belongs to a family of proteins that regulate a variety of cellular processes by interacting with beta-galactoside moieties present in glycoproteins. Galectin-8 has two carbohydrate recognition domains linked ...