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Evaluation of the genotoxic potential due to the action of an effluent contaminated with chromium, by the comet assay in CHO-K1 cultures
(2005-12-01)
The comet assay technique has been considered to be more efficient in the biomonitoring of aquatic environments that the micronucleus and sister chromatid exchange techniques. The comet assay has been used to determine ...
Putative mechanisms of genotoxicity induced by fluoride: a comprehensive review
(Springer Heidelberg, 2017)
Genotoxicity is the ability of an agent to produce damage on the DNA molecule. Considering the strong evidence for a relationship between genetic damage and carcinogenesis, to elucidate the putative mechanisms of genotoxicity ...
In vitro metabolism effect on genotoxicity and antigenotoxicity of Agaricus blazei organics and aqueous extracts by the comet assay
(2006-09-01)
There is high interest in the natural products properties due to their use in popular medicine. Agaricus blazei Murrill ss. Heinem. (Ab) is native to Brazil and has been widely disseminated because its medicinal properties. ...
Lack of genotoxicity induced by endogenous and synthetic female sex hormones in peripheral blood cells detected by alkaline Comet assay
(Wiley-Blackwell, 2007-06-01)
The etiology of hormone-induced cancers has been considered to be a combination of genotoxic and epigenetic events. Currently, the Comet assay is widely used for detecting genotoxicity because it is relatively simple, ...
Genotoxicity and antigenotoxicity assessment of shiitake (Lentinula edodes (Berkeley) Pegler) using the Comet assay
(Sociedade Brasileira de Genética, 2004-01-01)
The mushroom shiitake (Lentinula edodes (Berkeley) Pegler) is been widely consumed in many countries, including Brazil, because of its pleasant flavor and reports of its therapeutic properties, although there is little ...
Setting Time Affects In Vitro Biological Properties of Root Canal Sealers
(2013-09-30)
Introduction: Biocompatibility of root canal sealers is important because of the long-term contact of their eluates and/or degradation products with periapical tissues. The literature still lacks studies about the genotoxic ...
Mutagenic and genotoxic effect of hydroxyurea
(2011-12-15)
The hydroxyurea, a cytotoxic drug, is the mainly available therapeutical strategy for the treatment of sickle cell disease. This study aimed to evaluate the mutagenic and genotoxic potential of the hydroxyurea through the ...
Cytotoxicity and Genotoxicity of Root Canal Sealers Based on Mineral Trioxide Aggregate
(Elsevier B.V., 2012-04-01)
Introduction: MTA has good biological properties, and it is a mineralization-inducing material with different indications in endodontics. Initially this material was not recommended as root canal sealer. However, a resin ...
Protective effect of bixin on cisplatin-induced genotoxicity in PC12 cells
(Pergamon-Elsevier B.V. Ltd, 2012-02-01)
Bixin is the main carotenoid found in annatto seeds (Bixa orellana L.) and is responsible for their reddish-orange color. The antioxidant properties of this compound are associated with its ability to scavenge free radicals, ...
Investigation of the Genotoxic Potential of the Waters of a River Receiving Tannery Effluents by Means of the in vitro Comet Assay
(2003-12-01)
The comet assay has been described as an efficient tool for the detection of changes in the DNA molecule of cells exposed to contaminating agents in vivo and in vitro. The possible environmental contamination due to the ...