Now showing items 1-10 of 1016
An evaluation of the genotoxic and cytotoxic effects of the anti-obesity drugs sibutramine and fenproporex
(SAGE PUBLICATIONS LTD, 2010)
Anti-obesity medications deserve special considerations at the present time due to an increasing number of overweight and obese people who require these therapeutic alternatives. Obesity is positively associated with several ...
Evaluation of the genotoxic potential due to the action of an effluent contaminated with chromium, by the comet assay in CHO-K1 cultures
The comet assay technique has been considered to be more efficient in the biomonitoring of aquatic environments that the micronucleus and sister chromatid exchange techniques. The comet assay has been used to determine ...
Chemoprevention assessment, genotoxicity and cytotoxicity of flavonoids from Inga laurina leaves (FABACEAE)
This study aimed to identify and evaluate the cytotoxicity, genotoxicity, antigenotoxicity and chemoprevention assessment of flavonoids myricetin-3-O-(2″-O-galloyl)-α-rhamnopyranoside and myricetin-3-rhamnoside from Inga ...
Analysis of Aloe vera cytotoxicity and genotoxicity associated with endodontic medication and laser photobiomodulation
This study aims to evaluate, in vitro, the effect of Aloe vera associated with endodontic medication, with or without laser photobiomodulation (FTL) irradiation in FP6 human pulp fibroblasts. The materials were divided ...
In Vitro Genotoxic Effects of Four Helichrysum Species in Human Lymphocytes Cultures
(Sociedad de Biología de Chile, 2010)
Mutagenic and genotoxic effect of hydroxyurea
(International Journal Of Biomedical Science : Ijbs, 2011)
The hydroxyurea, a cytotoxic drug, is the mainly available therapeutical strategy for the treatment of sickle cell disease. This study aimed to evaluate the mutagenic and genotoxic potential of the hydroxyurea through the ...
Genotoxic effect of phenol on the cells of onion (Allium cepa ) roots
The roots of onion (Allium cepa ) stand out for having cells with large size and small number of chromosomes. These characteristics make them useful in bioassays for the measurement of a variety of cytogenetic and morphological ...
In vitro metabolism effect on genotoxicity and antigenotoxicity of Agaricus blazei organics and aqueous extracts by the comet assay
There is high interest in the natural products properties due to their use in popular medicine. Agaricus blazei Murrill ss. Heinem. (Ab) is native to Brazil and has been widely disseminated because its medicinal properties. ...
Assessing genotoxic effects in fish from a marine protected area influenced by former mining activities and other stressors
The goal of the current study was to evaluate different genotoxicity tools in order to assess a marine protected area (MPA) affected by former mining activities and urban settlements. A catfish (Cathorops spixii) was ...
Using the comet and micronucleus assays for genotoxicity studies: a review
Physical, chemical and biological agents can act in the DNA, resulting in mutation involved in cancer. Thus, genotoxic tests are required by regulatory agencies in order to evaluate potential risk of cancer. Among these ...