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Genetic structure of personality factors and bipolar disorder in families segregating bipolar disorder
(Journal of Affective Disorders xxx (2011) xxx–xxx, 2011)
Bipolar disorder (BPD) has been associated with variations in personality dimensions,
but the nature of this relationship has been unclear. Inthis study, theheritabilities of BPDandtheBig
Five personality factors and the ...
Genetic analysis of the dry forest timber tree Sideroxylon capiri in Costa Rica using AFLP
(2015-01)
Sideroxylon capiri (“Tempisque”) is a threatened and economically important timber species in the dry forest of Costa Rica. To assess the extent of the genetic diversity between and within populations of this species, 86 ...
Estudio intergeneracional de la mutación que causa la distrofia miotónica de tipo 1 en Costa Rica
(Revista de Neurología 2003; 36: 20-25, 2003-01-01)
Introduction. Myotonic dystrophy type 1 is a neuromuscular, degenerative and progressive disease, with an autosomal
dominant pattern of inheritance, variable eTressivity and incomplete penetrance. The genetic defect is ...
Disease-associated CAG·CTG triplet repeats expand rapidly in non-dividing mouse cells, but cell cycle arrest is insufficient to drive expansion
(Nucleic Acids Research 42(11) p. 7047–7056, 2014-05-01)
Genetically unstable expanded CAG·CTG trinucleotide repeats are causal in a number of human disorders, including Huntington disease and myotonic dystrophy type 1. It is still widely assumed that DNA polymerase slippage ...
Aspectos genéticos y moleculares de la distrofia miotónica
(1999)
Mvotonic Dystrophy is a multisystemic illness which affects several tissues such as the muscle, the brain and some endocrine tissues. It presents a dominant of autosomic inheritance with incomplete penetrance and variable ...
Parental age effects, but no evidence for an intrauterine effect in the transmission of myotonic dystrophy type 1
(European Journal of Human Genetics p.1-8, 2014-07-23)
Myotonic dystrophy type 1 (DM1) is caused by the expansion of an unstable CTG repeat (g.17294_17296(45_1000)) with more repeats associated with increased disease severity and reduced age at onset. Expanded disease-associated ...
Mitochondrial DNA “clock” for the Amerinds and its implications for timing their entry into North America
(1994-02)
Students of the time of entry of the ancestors of the Amerinds into the New World are divided into two camps, one favoring an "early" entry [more than approximately 30,000 years before the present (YBP)], the other favoring ...
Seasonal Variation of Peripheral Blood Leukocyte Telomere Length in Costa Rica: A Population-Based Observational Study
(2014)
ABSTRACT: Objectives: Peripheral blood leukocyte telomere length (LTL) is increasingly being used as a biomarker of aging, but its natural variation in human populations is not well understood. Several other biomarkers ...
Aspectos genéticos y moleculares de las enfermedades miotónicas
(Revista de Neurología 38 (7) p 668-674, 2004)
Aim. The aim is to review the molecular and genetic aspects of the dystrophic and no-dystrophic myotonias. Background.
Myotonic diseases are hereditary conditions of the skeletal muscle, classified in two groups depending ...
Brain structure–function associations in multi-generational families genetically enriched for bipolar disorder
(2015-05)
Recent theories regarding the pathophysiology of bipolar disorder suggest contributions of both neurodevelopmental and neurodegenerative processes. While structural neuroimaging studies indicate disease-associated ...