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Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice
(BioMed Central, 2019-06)
Go is a member of the pertussis toxin-sensitive Gi/o family. Despite its abundance in the central nervous system, the precise role of Go remains largely unknown compared to other G proteins. In the present study, we explored ...
Aromatic clusters in protein-protein and protein-drug complexes
(BioMed Central, 2020-05)
Aromatic rings are important residues for biological interactions and appear to a large extent as part of protein-drug and protein-protein interactions. They are relevant for both protein stability and molecular recognition ...
Consistent prediction of GO protein localization
(Nature Publishing Group, 2018-12)
The GO-Cellular Component (GO-CC) ontology provides a controlled vocabulary for the consistent description of the subcellular compartments or macromolecular complexes where proteins may act. Current machine learning-based ...
Molecular cloning and sequence determination of a cDNA coding for the α-subunit of a Go-type protein of Xenopus laevis oocytes
(1989)
Xenopus laevis oocytes are cells ideally suited to the study of signal transduction and of the G-proteins that are involved in this process. A X. laevis cDNA library in λgt10 has been screened with a mixture of three ...
APP/Go protein Gβγ-complex signaling mediates Aβ degeneration and cognitive impairment in Alzheimer's disease models
(Elsevier Science Inc, 2018-04-20)
Deposition of amyloid-β (Aβ), the proteolytic product of the amyloid precursor protein (APP), might cause neurodegeneration and cognitive decline in Alzheimer's disease (AD). However, the direct involvement of APP in the ...
Balance of Go1α and Go2α expression regulates motor function via the striatal dopaminergic system
(Wiley, 2018)
Abstract: The heterotrimeric G-protein Go with its splice variants, Go1α and Go2α, seems to be involved in the regulation of motor function but isoform-specific effects are still unclear. We found that Go1α-/- knockouts ...
APP signaling in Alzheimer's disease
(Impact Journals, 2018-11)
A large body of evidence supports the Amyloid β (Aβ) cascade hypothesis underlying neurodegeneration in Alzheimer’s disease (AD). Although the mechanism by which Aβ induces neuronal dysfunction and death is still matter ...
Genetic analysis of phosphoprotein and matrix protein of rabies viruses isolated in Brazil
(Japan Soc Vet Sci, 2014)
Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice
(BMC, 2019)
Abtract: Go is a member of the pertussis toxin-sensitive Gi/o family. Despite its abundance in the central nervous system, the precise role of Go remains largely unknown compared to other G proteins. In the present study, ...