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Full-length galectin-8 and separate carbohydrate recognition domains: the whole is greater than the sum of its parts?
(Portland Press, 2020-06)
Galectin-8 (Gal-8) is a tandem-repeat type galectin with affinity for β-galactosides, bearing two carbohydrate recognition domains (CRD) connected by a linker peptide. The N- and C-terminal domains (Gal-8N and Gal-8C) share ...
Cracking the “Sugar Code”: A Snapshot of N- and O-Glycosylation Pathways and Functions in Plants Cells
(Frontiers Media, 2021-02)
Glycosylation is a fundamental co-translational and/or post-translational modification process where an attachment of sugars onto either proteins or lipids can alter their biological function, subcellular location and ...
A highly stable, non-digestible lectin from Pomacea diffusa unveils clade-related protection systems in apple snail eggs
(Company of Biologists, 2020-10-08)
The acquisition of egg protection is vital for species survival. Poisonous eggs from Pomacea apple snails have defensive macromolecules for protection. Here we isolated and characterized a novel lectin called PdPV1 that ...
Estudo de glicídios de Angiostrongylus cantonensis e o papel no imunodiagnóstico
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2015)
Angiostrongylus cantonensis is a nematode parasite, main etiologic agent of the eosinophilic meningitis (EM) in humans, a disease endemic in many tropical and sub tropical countries. The diagnosis of EM involves clinical ...
Estudo de glicídios de Angiostrongylus cantonensis e o papel no imunodiagnóstico
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2015)
Angiostrongylus cantonensis is a nematode parasite, main etiologic agent of the eosinophilic meningitis (EM) in humans, a disease endemic in many tropical and sub tropical countries. The diagnosis of EM involves clinical ...
Targeted glycoproteomic identification of cancer cell glycosylation
(Oxford Univ Press Inc, 2009-05)
GalMBP is a fragment of serum mannose-binding protein that has been modified to create a probe for galactose-containing ligands. Glycan array screening demonstrated that the carbohydrate-recognition domain of GalMBP ...
Parasite-host glycan interactions during Trypanosoma cruzi infection: trans-Sialidase rides the show
(Elsevier Science, 2020-05)
Many important pathogen-host interactions rely on highly specific carbohydrate binding events. In the case of the protozoan Trypanosoma cruzi, the causative agent of Chagas disease, glycointeractions involving sialic acid ...
A Unique Galectin Signature in Human Prostate Cancer Progression Suggests Galectin-1 as a Key Target for Treatment of Advanced Disease
(American Association for Cancer Research, 2013-01)
Galectins, a family of glycan-binding proteins, influence tumor progression by modulating interactions between tumor, endothelial, stromal, and immune cells. Despite considerable progress in identifying the roles of ...
Efecto de la eliminación enzimática de N-glúcidos sobre la estructura y propiedades inmunogénicas y antitumorales de las hemocianinas de moluscos en mamíferos
(Universidad de Chile, 2018)
Las hemocianinas, glicoproteínas de alto peso molecular cuya función más conocida es transportar el oxígeno en algunos moluscos, son ampliamente utilizadas en aplicaciones biomédicas y biotecnológicas. La hemocianina más ...