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Validation of an enzyme-linked inmunosorbent assay (ELISA) kit for the quantification of gliadins in medicines and cosmetics
(2021)
Celiac disease is caused by intolerance to gluten and the only current treatment is a
gluten-free diet. Gliadins are the alcohol-soluble proteins that make up the majority of
gluten and are the ones that have the most ...
Circular Dichroism and Electron Microscopy Studies In Vitro of 33-mer Gliadin Peptide Revealed Secondary Structure Transition and Supramolecular Organization
(Wiley, 2014-01)
Gliadin, a protein present in wheat, rye, and barley, undergoes incomplete enzymatic degradation during digestion, producing an immunogenic 33-mer peptide, LQLQPF(PQPQLPY)3 PQPQPF. The special features of 33-mer that ...
Insights into gliadin supramolecular organization at digestive pH 3.0
(Elsevier Science, 2018-05-01)
Alpha-gliadin is a highly immunogenic protein from wheat, which is associated with many human diseases, like celiac disease and non-celiac gluten sensitivity. Because of that, gliadin solution is subject to intense biomedical ...
Self-organization of gliadin in aqueous media under physiological digestive pHs
(Elsevier Science, 2016-05)
Here we showed that gliadin, a complex protein system related to celiac disease and other human diseases, is spontaneously self-organized in a very dilute solution at pH 3.0 and 7.0 in water under low ionic strength (10 ...
Functionality of lactic acid bacteria peptidase activities in the hydrolysis of gliadin-like fragments
(Wiley Blackwell Publishing, Inc, 2008-11)
Aims: To evaluate the role of the peptidase activities from sourdough lactic acid bacteria (LAB) in the degradation of α-gliadin fragments. Methods and Results: Different proline-containing substrates were hydrolysed by ...
Electrochemical immunosensor modified with carbon nanofibers coupled to a paper platform for the determination of gliadins in food samples
(Royal Society of Chemistry, 2019-04)
The gluten-free diet is a unique, effective treatment for different conditions related to gluten consumption. Therefore, it is crucial the availability of new methodologies for the sensitive and specific determination of ...
IgG anti-gliadin determination with an immunological microfluidic system applied to the automated diagnostic of the celiac disease
(Springer Heidelberg, 2010-04-12)
In the present article, a novel microfluidic immunosensor coupled with electrochemical detection for anti-gliadin IgG antibody quantification is proposed. This device represents an important tool for a fast, simple, ...
Pepsin digest of gliadin forms spontaneously amyloid-like nanostructures influencing the expression of selected pro-inflammatory, chemoattractant, and apoptotic genes in Caco-2 cells: implications for gluten-related disorders
(Wiley VCH Verlag, 2021-08)
Scope: Proteolysis-resistant gliadin peptides are intensely investigated in biomedical research relates to celiac disease and gluten-related disorders. Herein, the first integrated supramolecular investigation of pepsin-digested ...