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Deficiência de GH na vida adulta: como diagnosticar e quando tratar?
(Sociedade Brasileira de Endocrinologia e Metabologia, 2008)
A deficiência de hormônio do crescimento (DGH) na vida adulta (DGHA) é entidade clínica bem estabelecida, com características heterogêneas e na qual as principais etiologias são as neoplasias da região hipotálamo-hipofisária ...
Genetic Mutations in the GH/IGF Axis
(Medical Media, 2018-09)
The GH/IGF axis plays an important role in the control of pre and postnatal growth. At least 48 monogenic defects have been described affecting the production, secretion, and action of GH and IGFs. Molecular defects of the ...
Genetic disorders of GH action pathway
(Churchill Livingstone, 2018-02)
While insensitivity to GH (GHI) is characterized by low IGF-I levels, normal or elevated GH levels, and lack of IGF-I response to GH treatment, IGF-I resistance is characterized by elevated IGF-I levels with normal/high ...
GH modulates hepatic epidermal growth factor signaling in the mouse.
(BioScientifica, 2010-03)
Epidermal growth factor (EGF) is a key regulator of cell survival and proliferation involved in the pathogenesis and progression of different types of cancer. The EGF receptor (EGFR) is activated by binding of the specific ...
Ames dwarf (Prop1df/Prop1df) mice display increased sensitivity of the major GH-signaling pathways in liver and skeletal muscle
(Elsevier, 2010-04)
CONTEXT: Growth hormone (GH) is an anabolic hormone that regulates growth and metabolism. Ames dwarf mice are natural mutants for Prop1, with impaired development of anterior pituitary and undetectable levels of circulating ...
Propriedades de um homeomorfismo GH estávelProperties of a stable GH homeomorphism
(Universidade Federal de UberlândiaBrasilPrograma de Pós-graduação em Matemática, 2018)
Arginine induces GH gene expression by activating NOS/NO signaling in rat isolated hemi-pituitaries
(Associação Brasileira de Divulgação Científica, 2012)
The amino acid arginine (Arg) is a recognized secretagogue of growth hormone (GH), and has been shown to induce GH gene expression. Arg is the natural precursor of nitric oxide (NO), which is known to mediate many of the ...
Characterization of two GH5 endoglucanases from termite microbiome using synthetic metagenomics
(Springer, 2020-08-20)
Here, we characterize two novel GH5 endoglucanases (GH5CelA and GH5CelB) from an uncultured bacterium identified in termite gut microbiomes. Both genes were codon-optimized, synthetized, cloned, and expressed as recombinant ...
Decreased ghrelin-induced GH release in thyrotoxicosis: comparison with GH-releasing peptide-6 (GHRP-6) and GHRH
(Springer, 2007-03-01)
In thyrotoxicosis GH response to several stimuli is impaired, but there is no data on ghrelininduced GH release in these patients. Ghrelin is a potent GH secretagogue and it also increases glucose levels in men. the aim ...
Paenibacillus sp. A59 GH10 and GH11 Extracellular Endoxylanases: Application in Biomass Bioconversion
(Springer New York LLC, 2017-12)
The cost-efficient degradation of xylan to fermentable sugars is of particular interest in second generation bioethanol production, feed, food, and pulp and paper industries. Multiple potentially secreted enzymes involved ...