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Discordant Nadir GH After Oral Glucose and IGF-I Levels on Treated Acromegaly: Refining the Biochemical Markers of Mild Disease Activity
(GEORG THIEME VERLAG KG, 2010)
Biochemical markers for remission on acromegaly activity are controversial. We studied a subset of treated acromegalic patients with discordant nadir GH levels after oral glucose tolerance test (oGTT) and IGF-I values to ...
Deficiência de GH na vida adulta: como diagnosticar e quando tratar?
(Sociedade Brasileira de Endocrinologia e Metabologia, 2008)
A deficiência de hormônio do crescimento (DGH) na vida adulta (DGHA) é entidade clínica bem estabelecida, com características heterogêneas e na qual as principais etiologias são as neoplasias da região hipotálamo-hipofisária ...
Genetic Mutations in the GH/IGF Axis
(Medical Media, 2018-09)
The GH/IGF axis plays an important role in the control of pre and postnatal growth. At least 48 monogenic defects have been described affecting the production, secretion, and action of GH and IGFs. Molecular defects of the ...
Growth hormone (GH) responses to GH-releasing peptide and to GH-releasing hormone in GH-deficient children
(1995)
The GH-releasing peptides (GHRPs) are a family of hexa- and heptapeptides that specifically stimulate GH secretion in normal adults and children. They would be an attractive potential form of therapy for GH deficiency (GHD) ...
Genetic disorders of GH action pathway
(Churchill Livingstone, 2018-02)
While insensitivity to GH (GHI) is characterized by low IGF-I levels, normal or elevated GH levels, and lack of IGF-I response to GH treatment, IGF-I resistance is characterized by elevated IGF-I levels with normal/high ...
Estatura final em pacientes com Síndrome de Turner tratadas com hormônio de crescimento
(Universidade Federal de São Paulo (UNIFESP), 2020-04-30)
Objective: To analyze the final height (EF) in women with Turner syndrome (ST) treated with growth hormone (GH) and to identify predictors of a better response to GH. Method: Retrospective study including 107 karyotypeconfirmed ...
From growth hormone-releasing peptides to ghrelin: discovery of new modulators of GH secretion
(Sociedade Brasileira de Endocrinologia e Metabologia, 2006-02-01)
Growth hormone (GH)-releasing hormone and somatostatin modulate GH secretion. A third mechanism has been discovered in the last decade, involving the action of GH secretagogues. Ghrelin is a new acylated peptide produced ...
GH modulates hepatic epidermal growth factor signaling in the mouse.
(BioScientifica, 2010-03)
Epidermal growth factor (EGF) is a key regulator of cell survival and proliferation involved in the pathogenesis and progression of different types of cancer. The EGF receptor (EGFR) is activated by binding of the specific ...