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RET-independent signaling by GDNF ligands and GFRα receptors
(Springer, 2020-07)
The discovery in the late 1990s of the partnership between the RET receptor tyrosine kinase and the GFRα family of GPI-anchored co-receptors as mediators of the effects of GDNF family ligands galvanized the field of ...
Lrig1 and lrig3 cooperate to control ret receptor signaling, sensory axonal growth and epidermal innervations
(Company of Biologists, 2021-08)
Negative feedback loops represent a regulatory mechanism that guarantees that signaling thresholds are compatible with a physiological response. Previously, we established that Lrig1 acts through this mechanism to inhibit ...
New insights into the control of neurotrophic growth factor receptor signaling: Implications for nervous system development and repair
(Wiley Blackwell Publishing, Inc, 2012-12)
Neurotrophic growth factors control neuronal development by activating specific receptor tyrosine kinase positive signaling pathways, such as Ras-MAPK and PI3K-Akt cascades. Once activated, neurotrophic factor receptors ...
Small-Molecule Ligands that bind the RET receptor activate neuroprotective signals independent of but modulated by coreceptor GFR α 1
(American Society for Pharmacology and Experimental Therapeutics, 2020-08)
Glial cell line-derived neurotrophic factor (GDNF) binds the GFRα1 receptor, and the GDNF-GFRα1 complex binds to and activates the transmembrane RET tyrosine kinase to signal through intracellular Akt/Erk pathways. To ...
Efectos modulatorios del litio sobre la cascada de señalización mediada por fosfoinositoles en cultivo neuronal primario
(Universidad Nacional de ColombiaBogotá - Ciencias - Maestría en Ciencias - BiologíaDepartamento de BiologíaFacultad de CienciasBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá, 2021)
El litio es el fármaco estándar para el tratamiento del trastorno bipolar. Sin embargo, su mecanismo de acción a nivel celular no está dilucidado. En líneas celulares en nuestro laboratorio se observaron efectos modulatorios ...