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Coordinated expression of galectin-3 and galectin-3-binding sites in malignant mammary tumors: implications for tumor metastasis
(OXFORD UNIV PRESS INC, 2010)
Galectin-3 is a glycan-binding protein that mediates cell-cell and/or cell-extracellular matrix (ECM) interactions. Although galectin-3 is implicated in the progression of various types of cancers, the mechanisms by which ...
Galectin-Levels Are Elevated in Infants Born Preterm Due to Amniotic Infection and Rapidly Decline in the Neonatal Period
(Frontiers Media, 2021-02-25)
Galectin (gal)-1, -3, and -9 are members of a family of glycan binding proteins that mediate complex interactions between decidual, inflammatory and trophoblast cells modulating several processes during gestation, control ...
Galectin signature in normal pregnancy and preeclampsia
(Elsevier, 2013-08)
Members of the galectin family are expressed within the female reproductive tract and have been shown to be involved in multiple biological functions that support the progression of pregnancy. Specific expression patterns ...
The role of Galectin-1 and Galectin-3 in the mucosal immune response to Citrobacter rodentium infection
(Public Library Of Science, 2014-09)
Despite their abundance at gastrointestinal sites, little is known about the role of galectins in gut immune responses. We have therefore investigated the Citrobacter rodentium model of colonic infection and inflammation ...
Galectins: structure, function and therapeutic potential
(Cambridge University Press, 2008-10)
Galectins are a family of animal lectins that bind beta-galactosides. Outside the cell, galectins bind to cell-surface and extracellular matrix glycans and thereby affect a variety of cellular processes. However, galectins ...
An integrated computational analysis of the structure, dynamics, and ligand binding interactions of the human galectin network
(American Chemical Society, 2011-08)
Galectins, a family of evolutionarily conserved animal lectins, have been shown to modulate signaling processes leading to inflammation, apoptosis, immunoregulation, and angiogenesis through their ability to interact with ...
Spatial expression of two anti-inflammatory mediators, annexin 1 and galectin-1, in nasal polyposis
(Blackwell Publishing, 2006-10-01)
Background There is renewed interest in the role played by specific counter-regulatory mechanisms to control the inflammatory host response, poorly investigated in human pathology. Here, we monitored the expression of two ...
Antibodies against galectin-8 in patients with systemic lupus erythematosus
(SOC MEDICA SANTIAGO, 2006)
Background: The family of lectins known as galectins (galectins 1-14) are involved in the regulation of the immune system and in oncogenesis. During a search for antigens recognized by antibodies produced by a patient with ...