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Determinants of differential functions of galectin-8 on T cells and tumoral cells : interplay of galectin-8 isoforms, integrin and growth factor signaling pathways.
(2014)
Galectins are a subfamily of lectins involved in a variety of cellular processes mainly related with the immune system and cancer. Galectins are secreted through unconventional mechanisms, because they lack a signal peptide, ...
C57BL/6 α-1,3-Galactosyltransferase knockout mouse as an animal model for experimental Chagas disease
(American Chemical Society, 2020)
The leading animal model of experimental Chagas disease, the mouse, plays a significant role in studies for vaccine development, diagnosis, and human therapies. Humans, along with Old World primates, alone among mammals, ...
An acetylation site in lectin domain modulates the biological activity of polypeptide GalNAc-transferase-2
(De Gruyter, 2012-12)
Polypeptide GalNAc-transferases (ppGalNAc-Ts) are a family of enzymes that catalyze the initiation of mucintype O -glycosylation. All ppGalNAc-T family members contain a common (QXW) 3 motif, which is present in the R-type ...
C57BL/6 alpha-1,3-Galactosyltransferase Knockout Mouse as an Animal Model for Experimental Chagas Disease
(American Chemical Society, 2023)
Amplifying immunogenicity of prospective Covid-19 vaccines by glycoengin- eering the coronavirus glycan-shield to present α-gal epitopes
The many carbohydrate chains on Covid-19 coronavirus SARS-CoV-2 and its S-protein form a glycanshield that masks antigenic peptides and decreases uptake of inactivated virus or S-protein vaccines by APC.
Studies on ...
Carboidrato -Gal acoplado à VLP como candidato vacinal contra leishmaniose causada por Leishmania infantum e L. amazonensis
(Universidade Federal de Minas GeraisUFMG, 2016-09-26)
The clinical manifestations of leishmaniasis depend on a complex interaction between the parasite species and the host immune system. Carbohydrates have been pointed as essential for virulence and viability of Leishmania ...
Neuronal death in Drosophila triggered by GAL4 accumulation
(Wiley, 2007-12)
The GAL4/UAS system has been extensively employed in Drosophila to control gene expression in defined spatial patterns. More recently this system has been successfully applied to express genes involved in neurodegeneration ...