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Potent in vitro anti-Trypanosoma cruzi activity of pyridine-2-thiol N-oxide metal complexes having an inhibitory effect on parasite-specific fumarate reductase
(SPRINGER, 2008-06)
In the search for new therapeutic tools against
Chagas disease (American trypanosomiasis) palladium and
platinum complexes of the bioactive ligand pyridine-2-
thiol N-oxide were exhaustively characterized and evaluated
in ...
The contribution of genes required for anaerobic respiration to the virulence of Salmonella enterica serovar Gallinarum for chickens
(Sociedade Brasileira de Microbiologia, 2009-12-01)
Salmonella enterica serovar Gallinarum (SG) is an intracellular pathogen of chickens. To survive, to invade and to multiply in the intestinal tract and intracellularly it depends on its ability to produce energy in anaerobic ...
The contribution of genes required for anaerobic respiration to the virulence of Salmonella enterica serovar Gallinarum for chickens
(Sociedade Brasileira de Microbiologia, 2009-12-01)
Salmonella enterica serovar Gallinarum (SG) is an intracellular pathogen of chickens. To survive, to invade and to multiply in the intestinal tract and intracellularly it depends on its ability to produce energy in anaerobic ...
Mitochondrial bioenergetics and redox state are unaltered in Trypanosoma cruzi isolates with compromised mitochondrial complex I subunit genes
(SPRINGER/PLENUM PUBLISHERS, 2009)
In trypanosomatids the involvement of mitochondrial complex I in NADH oxidation has long been debated. Here, we took advantage of natural Trypanosoma cruzi mutants which present conspicuous deletions in ND4, ND5 and ND7 ...
Identification and Unusual Properties of the Master Regulator FNR in the Extreme Acidophile Acidithiobacillus ferrooxidans
(Facultad de Medicina y Ciencia, 2019)
The ability to conserve energy in the presence or absence of oxygen provides a metabolic versatility that confers an advantage in natural ecosystems. The switch between alternative electron transport systems is controlled ...
The contribution of genes required for anaerobic respiration to the virulence of Salmonella enterica serovar Gallinarum for chickens
(Sociedade Brasileira de Microbiologia, 2014)
Electrophiles modulate glutathione reductase activity via alkylation and upregulation of glutathione biosynthesis
(Elsevier, 2019)
Cells evolved robust homeostatic mechanisms to protect against oxidation or alkylation by electrophilic species.
Glutathione (GSH) is the most abundant intracellular thiol, protects cellular components from oxidation and ...
Probing the ArcA regulon under aerobic/ROS conditions in Salmonella enterica serovar Typhimurium
(BMC, 2013-09)
Background: Hydrogen peroxide (H2O2) is a reactive oxygen species (ROS), which is part of the oxidative burst encountered upon internalization of Salmonella enterica serovar Typhimurium (S. Typhimurium) by phagocytic cells. ...