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Genome profiling of fluoroquinolone-resistant uropathogenic Escherichia coli isolates from Brazil
(2021-01-01)
Urinary tract infections (UTIs) are a major public health concern in both community and hospital settings worldwide. Uropathogenic Escherichia coli (UPEC) is the main causative agent of UTI and increasingly associated with ...
Synthesis of Hybrid Fluoroquinolone-Boron Complexes and Their Evaluation in Cervical Cancer Cell Lines
(Hindawi, 2019-01)
Quinolones are a family of antimicrobial agents that have been used in antibacterial and anticancer chemotherapy. Fluoroquinolone targets DNA gyrase and topoisomerase IV enzymes affecting several cellular processes, like ...
SAR analysis of new dual targeting fluoroquinolones. Implications of the benzenesulfonyl group
(Bentham Science Publishers, 2012-05)
When a benzenesulfonyl moiety (BS) was bound to the N-piperazinyl ring of antibacterial fluoroquinolones (AMFQs) norfloxacin (NOR) or ciprofloxacin (CIP), the resulting benzenesulfonyl-fluoroquinolone (BSFQs) analogs showed ...
Occurrence, Distribution, and Ecological Risk of Fluoroquinolones in Rivers and Wastewaters
(Society of Environmental Toxicology and Chemistry, 2019-10)
The use of fluoroquinolones for the treatment of infections in humans and animals has increased in Argentina, and they can be found in large amounts in water bodies. The present study investigated the occurrence and ...
First report of plasmid-mediated fluoroquinolone efflux pump QepA in Escherichia coli clinical isolate ST68, in South America
(Elsevier, 2014-01)
This is the first report of the presence of qepA1 efflux pump gene in Escherichia coli clinical isolate from Argentina, which was associated to other plasmid-mediated quinolone resistance determinants, such as aac(6′)-Ib-cr ...
In vitro activity of fluoroquinolones against ocular bacterial isolates in São Paulo, Brazil
(Lippincott Williams & Wilkins, 2007-02-01)
Purpose: To compare the in vitro susceptibility profiles of bacterial ocular isolates and to determine minimum inhibitory concentrations (MICs) of gatifloxacin and moxifloxacin (fourth-generation fluoroquinolones) versus ...
Comparing the electrochemical degradation of the fluoroquinolone antibiotics norfloxacin and ciprofloxacin using distinct electrolytes and a BDD anode: evolution of main oxidation byproducts and toxicity
(Elsevier B.V., 2020-12-01)
The effects of the supporting electrolytes (SEs) Na2SO4, NaCl, Na2CO3, NaNO3, and Na3PO4 on the anodic oxidation of norfloxacin (NOR) and ciprofloxacin (CIPRO), assessed by the respective degradation kinetics and byproducts ...
Besifloxacin: A Critical Review of Its Characteristics, Properties, and Analytical Methods
(2018-03-04)
Bacterial conjunctivitis has high impact on the health of the population, since it represents more than a third of ocular pathologies reported by health services worldwide. There is a high incidence of bacterial resistance ...
Review of Properties and Analytical Methods for the Determination of Norfloxacin
(Taylor & Francis Inc, 2016-01-02)
The first-generation quinolones have their greatest potency against Gram-negative bacteria, but newly developed molecules have exhibited increased potency against Gram-positive bacteria, and existing agents are available ...