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Group 2 innate lymphoid cells exhibit progressively higher levels of activation during worsening of liver fibrosis
(Mexican Association of Hepatology, 2019-03)
Introduction: The interleukin-33/interleukin-13 pathway is involved in the immunopathology of liver fibrosis and recently characterized group 2 innate lymphoid cells (ILC2) were identified as profibrotic immune cells in ...
Piribedil for the Treatment of Motor and Non-motor Symptoms of Parkinson Disease
(Adis Int Ltd, 2016-08)
Dopamine agonists are well-established symptomatic medications for treating early and advanced Parkinson disease (PD). Piribedil was one of the first agonists to be marketed (1969) and is widely used as an extended-release ...
Pathomechanisms of autoimmune based testicular inflammation
(Frontiers Media, 2020-09)
Infection and inflammation of the male reproductive tract are relevant causes of infertility. Inflammatory damage occurs in the special immunosuppressive microenvironment of the testis, a hallmark termed testicular immune ...
Hepatic injury associated with Trypanosoma cruzi infection is attenuated by treatment with 15-deoxy-Δ 12,14 prostaglandin J 2
(Academic Press Inc Elsevier Science, 2016-11)
Trypanosoma cruzi, the etiological agent of Chagas´ disease, causes an intense inflammatory response in several tissues, including the liver. Since this organ is central to metabolism, its infection may be reflected in the ...
Sphingolipids as critical players in retinal physiology and pathology
(American Society for Biochemistry and Molecular Biology, 2021-01)
Sphingolipids have emerged as bioactive lipids involved in the regulation of many physiological and pathological processes. In the retina, they have been established toparticipate in numerousprocesses, suchas neuronal ...
Antigen-based nano-immunotherapy controls parasite persistence, inflammatory and oxidative stress, and cardiac fibrosis, the hallmarks of chronic chagas cardiomyopathy, in a mouse model of trypanosoma cruzi infection
(Multidisciplinary Digital Publishing Institute, 2020-02-21)
Chagas cardiomyopathy is caused by Trypanosoma cruzi (Tc). We identified two candidate antigens (TcG2 and TcG4) that elicit antibodies and T cell responses in naturally infected diverse hosts. In this study, we cloned TcG2 ...
Pathogenesis of domestic pigs submitted to mycobacterial sensitizations previous to experimental infection with Mycobacterium bovis
(INIA (España), 2022-03)
Aim of study: To demonstrate the virulence of a Mycobacterium bovis local pig isolate in order to contribute to a better understanding of the pathological and immunological consequences of M. bovis infection in previous ...
Cell-free DNA methylation as liquid biopsy for the assessment of fibrosis in patients with nonalcoholic steatohepatitis: a gap between innovation and implementation
(AME Publishing Company, 2017-04)
The presence of cfDNA in the circulating compartment was demonstrated three decades ago , leading to the emergence of liquid biopsy.However, the implementation of cfDNA methylation as a non-invasive molecular tool for the ...
SARS-CoV-2 Pathogenesis: Imbalance in the Renin-Angiotensin System Favors Lung Fibrosis
(Frontiers Research Foundation, 2020-06)
After SARS-CoV-2 infection, a major complication of those who survived to COVID-19 outbreak is the development of severe lung disease leading to pulmonary fibrosis. At earliest step of virus-host cell interaction when the ...
Molecular mechanisms and cellular contribution from lung fibrosis to lung cancer development
(MDPI, 2021-11-10)
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial lung disease (ILD) of unknown aetiology, with a median survival of 2–4 years from the time of diagnosis. Although IPF has unknown aetiology ...