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IGF-1 modulation of rat cardiac fibroblast behavior and gene expression is age-dependent
(TAYLOR & FRANCIS LTD, 2003-05)
The collagenous extracellular matrix (ECM) forms a stress-tolerant network that is essential for proper function of the vertebrate heart. Profound changes have been detected in the interstitial ECM concurrent with developmental ...
Tumor necrosis factor-astimulated membrane type 1-matrix metalloproteinase production is modulated by epidermal growth factor receptor signaling in human gingival fibroblasts
(Blackwell Munksgaard, 2007-12-11)
Membrane type 1-matrix metalloproteinase (MT1-
MMP) is a collagenolytic enzyme involved in connective tissue remodeling. In
periodontal tissues, either cytokines or growth factors regulate the production of
proteolytic ...
Induction of the myofibroblastic phenotype in human gingival fibroblasts by transforming growth factor-β1: Role of RhoA-ROCK and c-Jun N-terminal kinase signaling pathways
(2006)
Background and Objectives: Myofibroblastic differentiation is an important event in gingival wound healing and chronic inflammation. Transforming frowth factor-β 1 (TGF-β1) is a potent growth factor that has been implicated ...
Differential uPA expression by TGF-β1 in gingival fibroblasts
(2006)
Transforming Growth Factor-β1 (TGF-β1) plays a key role in connective tissue remodeling and inflammation. Under pathological conditions, like periodontal disease, fibroblasts may display an altered response to this growth ...
Induction of the myofibroblastic phenotype in human gingival fibroblasts by transforming growth factor-b1: role of RhoA-ROCK and c-Jun N-terminal kinase signaling pathways
(Blackwell Munksgaard Ltd, 2006-06-05)
Myofibroblastic differentiation is an important event
in gingival wound healing and chronic inflammation. Transforming frowth factorb
1 (TGF-b1) is a potent growth factor that has been implicated in this process.
Gingival ...
Epidermal growth factor stimulates urokinase-type plasminogen activator expression in human gingival fibroblasts. Possible modulation by genistein and curcumin
(Blackwell Munksgaard Ltd, 2004-04-08)
Regulation of the extracellular matrix turnover is a crucial process
in wound healing and the progress of periodontal disease. It has been proposed
that urokinase-type plasminogen activator (uPA), under the control of ...
Modulation of androgen receptor protein by culture conditions of human skin fibroblasts
(2002)
Cultures of skin fibroblasts show variation of androgen binding with culture conditions; binding variations are usually avoided by using confluent cultures. In this work, we analysed the effect of cell density and mitogenic ...
Tumor necrosis factor-α-stimulated membrane type 1-matrix metalloproteinase production is modulated by epidermal growth factor receptor signaling in human gingival fibroblasts
(2009)
Background and Objectives: Membrane type 1-matrix metalloproteinase (MT1-MMP) is a collagenolytic enzyme involved in connective tissue remodeling. In periodontal tissues, either cytokines or growth factors regulate the ...
Matrix metalloproteinase-8 regulates transforming growth factor-β1 levels in mouse tongue wounds and fibroblasts in vitro
(Academic Press Inc., 2014)
© 2014 Elsevier Inc. Matrix metalloproteinase-8 (MMP-8)-deficient mice (Mmp8-/-) exhibit delayed dermal wound healing, but also partly contradicting results have been reported. Using the Mmp8-/- mice we investigated the ...
Effect of platelet-rich plasma on cell adhesion, cell migration, and myofibroblastic differentiation in human gingival fibroblasts
(AMER ACAD PERIODONTOLOGY, 2008-04)
Background: Platelet-rich plasma is a blood-derived fraction that contains a high concentration of platelets and growth factors. It was proposed that the use of this platelet concentrate stimulates tissue repair. However, ...