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The role of forkhead box 1 (FOXO1) in the immune system: Dendritic cells, T cells, B cells, and hematopoietic stem cells
(2017-01-01)
Forkhead box-O (FOXO) transcription factors have a fundamental role in the development and differentiation of immune cells. FOXO1 and FOXO3 are FOXO members that are structurally similar and bind to the same conserved ...
FoxO1-Dio2 signaling axis governs cardiomyocyte thyroid hormone metabolism and hypertrophic growth
(Nature, 2020)
Forkhead box O (FoxO) proteins and thyroid hormone (TH) have well established roles in cardiovascular morphogenesis and remodeling. However, specific role(s) of individual FoxO family members in stress-induced growth and ...
Maternal diabetes induces FoxO1 and connexin 43 alterations in the heart of the developing embryo
(Elsevier, 2019)
Background: Maternal diabetes affects the embryonic, fetal and perinatal development and programs metabolic and cardiovascular alterations in the adult offspring. We recently reported cardiovascular alterations related to ...
FoxO3a nuclear localization and its association with beta-catenin and Smads in IFN-alfa-treated hepatocellular carcinoma cell lines
(Mary Ann Liebert Inc, 2014-11)
Interferon-a2b (IFN-a2b) reduces proliferation and increases apoptosis in hepatocellular carcinoma cells by decreasing b-catenin/TCF4/Smads interaction. Forkhead box O-class 3a (FoxO3a) participates in proliferation and ...
Insulin Suppresses Atrophy- and Autophagy-related Genes in Heart Tissue and Cardiomyocytes Through AKT/FOXO Signaling
(2013-06-14)
Insulin is an important regulator of the ubiquitin-proteasome system (UPS) and of lysosomal proteolysis in cardiac muscle. However, the role of insulin in the regulation of the muscle atrophy-related Ub-ligases atrogin-1 ...
Insulin Suppresses Atrophy- and Autophagy-related Genes in Heart Tissue and Cardiomyocytes Through AKT/FOXO Signaling
(2013-06-14)
Insulin is an important regulator of the ubiquitin-proteasome system (UPS) and of lysosomal proteolysis in cardiac muscle. However, the role of insulin in the regulation of the muscle atrophy-related Ub-ligases atrogin-1 ...
Methionine sulfoxide reductase A expression is regulated by the DAF-16/FOXO pathway in Caenorhabditis elegans
(WILEY, 2009)
P>The methionine sulfoxide reductase system has been implicated in aging and protection against oxidative stress. This conserved system reverses the oxidation of methionine residues within proteins. We analyzed one of the ...
Testosterone modulates FoxO3a and p53-related genes to protect C2C12 skeletal muscle cells against apoptosis
(Elsevier Science Inc, 2017-05)
The loss of muscle mass and strength with aging, sarcopenia, is a prevalent condition among the elderly, associated with skeletal muscle dysfunction and enhanced muscle cell apoptosis. We have previously demonstrated that ...
Extracellular ATP regulates FoxO family of transcription factors and cell cycle progression through PI3K/Akt in MCF-77 cells
(Elsevier, 2013-09)
Background: Forkhead Box-O (FoxO) transcription factors regulate the expression of many genes involved in suppression. Released nucleotides can regulate intracellular signaling pathways through membrane-bound purinergic ...
Avaliação de polimorfismos nos genes FOXO3A, AMPK EPOMC e sua relação com a obesidade mórbida
(Universidade Federal de Minas GeraisUFMG, 2013-02-18)
Morbid obesity (MO) is a metabolic disorder that affects people worldwide. Excessive fat accumulation in MO patients is frequently found to increase the risk for several co-morbidities, including cardiovascular disease and ...