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The Effect Of Fludarabine On Interferon-Gamma Production By Lymphoid Cells From Healthy Donors And Patients With B-Cell Chronic Lymphocytic Leukemia
(Ferrata Storti Foundation, 2006-12)
Fludarabine treatment in patients with B-cell chronic lymphocytic leukemia (B-CLL) can trigger or exacerbate the development of autoimmune hemolytic anemia (AHA) through a currently illdefined mechanism. We here show that ...
T-cell large granular lymphocytic leukemia: treatment experience with fludarabine
(HOSPITAL CLINICAS, UNIV SAO PAULOSÃO PAULO, 2012-07)
OBJECTIVES: The aim of this retrospective study was to investigate the results of T-cell large granular lymphocytic leukemia treatment with fludarabine by assessing the complete hematologic response, the complete molecular ...
In vitro susceptibility of CD4+ and CD8+ T cell subsets to fludarabine
(Pergamon-Elsevier Science Ltd, 2003-12)
Administration of the adenosine analogue fludarabine (FLU) in vivo induces a profound and prolonged T lymphopenia which mainly affects CD4+ cells. To better understand the mechanistic basis underlying this preferential ...
Correlation between chromosome damage and apoptosis induced by fludarabine and idarubicin in normal human lymphocytes
(Elsevier Ireland, 2002-02)
Fludarabine (FLU, a fluorinated purine analog) and idarubicin (IDA, a DNA-topoisomerase II poison) are frequently used in cancer chemotherapy. The effects of these drugs on cultured normal human lymphocytes were studied ...
Fludarabine induces apoptosis in chronic lymphocytic leukemia - the role of P53, Bcl-2, Bax, Mcl-1, and Bag-1 proteins
(Associação Brasileira de Divulgação Científica, 2006-03-01)
The expression of P53, Bcl-2, Bax, Bag-1, and Mcl-1 proteins in CD5/CD20-positive B-chronic lymphocytic leukemia (B-CLL) cells from 30 typical CLL patients was evaluated before and after 48 h of incubation with 10-6 M ...
Effects of rapamycin in combination with fludarabine on primary chronic lymphocytic leukemia cells
(Taylor & Francis Ltd, 2019-04)
Chronic lymphocytic leukemia (CLL) is the most commontype of leukemia in adults, characterized by the expansionof a population of monoclonal CD5þB-lymphocytesthat accumulate in the blood, bone marrow, and secondarylymphoid ...
O papel da Fludarabina no tratamento dos linfomas não Hodgkin de baixo grau de malignidadeThe role of Fludarabine in the treatment of low-grade non-Hodgkin's lymphomas
(Associação Brasileira de Hematologia e Hemoterapia e daSociedade Brasileira de Transplante de Medula Óssea, 2001)
Non-homologous end joining is the responsible pathway for the repair of fludarabine-induced DNA double strand breaks in mammalian cells
(Elsevier Science, 2008-11)
Fludarabine (FLU), an analogue of adenosine, interferes with DNA synthesis and inhibits the chain elongation leading to replication arrest and DNA double strand break (DSB) formation. Mammalian cells use two main pathways ...
Allogeneic bone marrow transplantation for severe aplastic anemia patients with risk factors poor prognosis: is fludarabine a requirement?
(Associação Brasileira de Hematologia e Hemoterapia e daSociedade Brasileira de Transplante de Medula Óssea, 2008)