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Neuronal filopodium formation induced by the membrane glycoprotein M6a (Gpm6a) is facilitated by coronin-1a, Rac1, and p21-activated kinase 1 (Pak1)
(Wiley Blackwell Publishing, Inc, 2016-04)
Stress-responsive neuronal membrane glycoprotein M6a (Gpm6a) functions in neurite extension, filopodium and spine formation and synaptogenesis. The mechanisms of Gpm6a action in these processes are incompletely understood. ...
Alanine Scanning Mutagenesis of the C-Terminal Cytosolic End of Gpm6a Identifies Key Residues Essential for the Formation of Filopodia
(Frontiers Research Foundation, 2018-09)
Neuronal membrane glycoprotein M6a (Gpm6a) is a protein with four transmembrane regions and the N- and the C-ends facing the cytosol. It functions in processes of neuronal development, outgrowth of neurites, and formation ...
Prenatal stress changes the glycoprotein GPM6A gene expression and induces epigenetic changes in rat offspring brain
(Taylor & Francis, 2014-01)
Prenatal stress (PS) exerts strong impact on fetal brain development and on adult offspring brain functions. Previous work demonstrated that chronic stress alters the mRNA expression of GPM6A, a neuronal glycoprotein ...
Altered expression of neuroplasticity-related genes in the brain of depressed suicides
(Pergamon-Elsevier Science Ltd, 2015-07)
Background: Expression of the neuronal membrane glycoprotein M6a (GPM6A), the proteolipid protein (PLP/DM20) family member, is downregulated in the hippocampus of chronically stressed animals. Its neuroplastic function ...
Evidence for a role of glycoprotein M6a in dendritic spine formation and synaptogenesis
(Academic Press Inc Elsevier Science, 2016-12)
Neuronal glycoprotein M6a belongs to the tetraspan proteolipid protein (PLP) family. Mutations in GPM6A gene have been related to mental disorders like schizophrenia, bipolar disorders and claustrophobia. M6a is expressed ...
Descriptive findings on the morphology of dendritic spines in the rat medial amygdala
(ELSEVIER IRELAND LTD, 2010)
The rat posterodorsal medial amygdala (MePD) is a brain area in which gonadal hormones induce notable plastic effects in the density of dendritic spines. Dendritic spines are post-synaptic specializations whose shape and ...
In Vivo and In Vitro Neuronal Plasticity Modulation by Epigenetic Regulators
(Springer, 2018-07)
Prenatal stress (PS) induces molecular changes that alter neural connectivity, increasing the risk for neuropsychiatric disorders. Here we analyzed —in the hippocampus of adult rats exposed to PS— the epigenetic signature ...
Ligand-mediated Galectin-1 endocytosis prevents intraneural H2O2 production promoting F-actin dynamics reactivation and axonal re-growth
(Elsevier Inc, 2016-09)
Axonal growth cone collapse following spinal cord injury (SCI) is promoted by semaphorin3A (Sema3A) signaling via PlexinA4 surface receptor. This interaction triggers intracellular signaling events leading to increased ...
Consequences of excessive plasticity in the hippocampus induced by perinatal asphyxia
(Academic Press Inc Elsevier Science, 2016-12)
Perinatal asphyxia (PA) is one of the most frequent risk factors for several neurodevelopmental disorders (NDDs) of presumed multifactorial etiology. Dysfunction of neuronal connectivity is thought to play a central role ...
Ligand-mediated Galectin-1 endocytosis prevents intraneural H2O2 production promoting F-actin dynamics reactivation and axonal re-growth
(2016)
Axonal growth cone collapse following spinal cord injury (SCI) is promoted by semaphorin3A (Sema3A) signaling via PlexinA4 surface receptor. This interaction triggers intracellular signaling events leading to increased ...