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Characterization of a multiprotein complex involved in excitation-transcription coupling of skeletal muscle
(Biomed Central, 2016)
Background: Electrical activity regulates the expression of skeletal muscle genes by a process known as “
excitation-transcription” (E-T) coupling. We have demonstrated that release of adenosine 5′-triphosphate (ATP) ...
Pannexin-1 and CaV1.1 show reciprocal interaction during excitation–contraction and excitation–transcription coupling in skeletal muscle
(Rockefeller Univ Press, 2021)
One of the most important functions of skeletal muscle is to respond to nerve stimuli by contracting. This function ensures
body movement but also participates in other important physiological roles, like regulation of ...
Eag1 potassium channel immunohistochemistry in the CNS of adult rat and selected regions of human brain
(PERGAMON-ELSEVIER SCIENCE LTD, 2008)
Eag1 (K(v)10.1) is the founding member of an evolutionarily conserved superfamily of voltage-gated K+ channels. In rats and humans Eag1 is preferentially expressed in adult brain but its regional distribution has only been ...
Calpain inhibition rescues troponin T3 fragmentation, increases Cav1.1, and enhances skeletal muscle force in aging sedentary mice
(Wiley Blackwell Publishing, Inc, 2016-06)
Loss of strength in human and animal models of aging can be partially attributed to a well-recognized decrease in muscle mass; however, starting at middle-age, the normalized force (force/muscle cross-sectional area) in ...
An integrated mechanism of cardiomyocyte nuclear Ca2+ signaling
(Academic Press, 2014)
© 2014 Elsevier Ltd. In cardiomyocytes, Ca2+ plays a central role in governing both contraction and signaling events that regulate gene expression. Current evidence indicates that discrimination between these two critical ...
Brain Na+, K+-ATPase activity In aging and disease
(Master Publishing Group, 2014-07)
Na+/K+ pump or sodium- and potassium-activated adenosine 5’-triphosphatase (Na+, K+-ATPase), its enzymatic version, is a crucial protein responsible for the electrochemical gradient across the cell membranes. It is an ion ...
Chasing Cardiac Physiology And Pathology Down The Camkii Cascade
(AMER PHYSIOLOGICAL SOCBETHESDA, 2015)