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Encapsulation of florfenicol by in situ crystallization into novel alginate-Eudragit RS® blended matrix for pH modulated release
(Editions Sante, 2019-12)
Florfenicol (FF) is a broad-spectrum antibiotic with the drawback of poor solubility in physiological media. Despite vehiculization of FF become an alternative, current devices usually showed low encapsulation efficiencies(EE) ...
Design and optimization of pH-sensitive Eudragit nanoparticles for improved oral delivery of triclabendazole
(Elsevier Science, 2022-04)
Design of Experiments (DoE) techniques were used to identify and optimize the parameters involved in the formulation of triclabendazole pH-sensitive Eudragit® nanoparticles (NPs). Using a Placket Burmann design, Eudragit® ...
A mechanistic approach for the optimization of loperamide loaded nanocarriers characterization: Diafiltration and mathematical modeling advantages
(Elsevier B.V., 2018)
© 2018 Elsevier B.V. Oral bioavailability of loperamide is restricted by its limited absorption in the gastrointestinal tract due to its poor aqueous solubility and its P-glycoprotein (Pgp) substrate characteristic. In ...
Poly(ε-caprolactone), Eudragit® RS 100 and poly(ε-caprolactone)/Eudragit® RS 100 blend submicron particles for the sustained release of the antiretroviral efavirenz
(Elsevier, 2013-02-01)
The design of simple and scalable drug delivery systems to target the central nervous system (CNS) could represent a breakthrough in the addressment of the HIV-associated neuropathogenesis. The intranasal (i.n.) route ...
Análisis sistemático de variables determinantes en la producción de nanopartículas poliméricas de Eudragit RS, RL y PCL por el método de nanoprecipitación
(2017)
En los últimos años la mayoría de los fármacos producidos por la industria farmacéutica innovadora presentan problemas de solubilidad acuosa, lo que reduce la biodisponibilidad de estos y dificulta su formulación. Una ...
Poloxamer 188-Coated Ammonium Methacrylate Copolymer Nanocarriers Enhance Loperamide Permeability across Pgp-Expressing Epithelia
(American Chemical Society, 2021-02)
Loperamide is a μ-opioid agonist with poor gastrointestinal absorption, mainly because of its modest aqueous solubility and being a P-glycoprotein (Pgp) efflux substrate. Nevertheless, studies associated with therapeutic ...
Phosphated crosslinked pectin as a potential excipient for specific drug delivery: preparation and physicochemical characterization
(John Wiley & Sons LtdChichesterInglaterra, 2010)
Estudio fisicoquímico de la liberación del diclofenac a partir de complejos polielectrolito-fármaco
(2011)
La investigación realizada se centró en el estudio sistemas formados a partir de complejos polielectrolito-fármaco, a partir de cuatro polímeros catiónicos (quitosán, eudragit® E, eudragit® RL y eudragit® RS) y el diclofenac, ...