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ErbB-2 nuclear function in breast cancer growth, metastasis and resistance to therapy
(BioScientifica, 2016-10)
Approximately 15-20% of breast cancers (BC) show either membrane overexpression of ErbB-2 (MErbB-2), a member of the ErbBs family of receptor tyrosine kinases, or ERBB2 gene amplification. Until the development of ...
Nuclear ErbB-2: A Novel Therapeutic Target in ErbB-2-Positive Breast Cancer?
(Springer, 2019-01)
Membrane overexpression of ErbB-2 (MErbB-2), a member of the ErbB family of receptor tyrosine kinases, occurs in 15– 20% of breast cancers (BC) and constitutes a therapeutic target in this BC subtype (ErbB-2-positive). ...
Neuregulin-1/erbB activities with focus on the susceptibility of the heart to anthracyclines
(Baishideng Publishing Group, 2014-07)
Neuregulin-1 (NRG1) signaling through the tyrosine kinase receptors erbB2 and erbB4 is required for cardiac morphogenesis, and it plays an essential role in maintaining the myocardial architecture during adulthood. The ...
The role of the Neuregulin-1/Erbb signaling pathway in cardiac morphogenesis and remodeling
(Sociedad Argentina de Fisiología, 2014-02)
Neuregulin-1 (NRG1) signaling through tyrosine kinase receptors erbB2 and erbB4 was revealed essential for cardiac development as mouse mutated in the Nrg1 or either cognate receptors Erbb2 or Erbb4 genes lack the formation ...
ErbB receptors and fatty acid synthase expression in aggressive head and neck squamous cell carcinomas
(Wiley-blackwellMaldenEUA, 2010)
Targeting ErbB-2 nuclear localization and function inhibits breast cancer growth and overcomes trastuzumab resistance
(Nature Publishing Group, 2015-06)
Membrane overexpression of ErbB-2/HER2 receptor tyrosine kinase (membrane ErbB-2 (MErbB-2)) has a critical role in breast cancer (BC). We and others have also shown the role of nuclear ErbB-2 (NErbB-2) in BC, whose presence ...
Definición de una nueva clase de complejo transcripcional: ErbB2 actúa de coactivador de Stat3 promoviendo la proliferación en tumores mamariosDefining a new class of transcriptional complex: ErbB2 acts as coactivator of Stat3 inducing proliferation in breast tumors
(Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires, 2010)
Expressão da proteína erbB-3/HER3 em câncer de pulmão pela técnica de imuno-histoquímica e sua correlação com características clínicopatológicas
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2008)
Four members belong to the erbB family, erbB1, erbB2, erbB3, and erbB4. Several reports have investigated the expression of members from this family, however with only few regarding to the role of erbB3 on non-small cell ...