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Participation of valine 171 in α-helix 5 of Bacillus thuringiensis Cry1Ab δ-endotoxin in translocation of toxin into Lymantria dispar midgut membranes
(2010-10-01)
The Cry1Ab δ-endotoxin V171C mutant protein exhibits a 25-fold increase in toxicity against Lymantria
dispar, which correlates with a faster rate of partitioning into the midgut membrane and slightly decreased
protein ...
Endotoxin-induced vascular endothelial cell migration is dependent on TLR4/NF-κB pathway, NAD(P)H oxidase activation, and transient receptor potential melastatin 7 calcium channel activity
(Elsevier Ltd, 2014)
Endothelial dysfunction is decisive and leads to the development of several inflammatory diseases. Endotoxemia-derived sepsis syndrome exhibits a broad inflammation-induced endothelial dysfunction. We reported previously ...
Two disulfide mutants in domain I of Bacillus thuringiensis Cry3Aa δ-endotoxin increase stability with no effect on toxicity
(2012-05)
To increase protein stability and test protein function, three double-cysteine mutations were individually introduced by protein engineering into the cysteinefree Cry3Aa δ-endotoxin from Bacillus thuringiensis.
These ...
Response to lipopolysaccharide in Octodon degus pups produces age-related sickness behavior but does not have effects in juveniles
(Wiley-Blackwell, 2019)
During vertebrate development, the immune function is inefficient and is mainly controlled by innate defense. While there have been detailed studies of various aspects of innate immune function, the effects of this function ...
Characterization of a mutant bacillus thuringiensis delta endotoxin with enhanced stability and toxicity
(2011-10)
The centrally located a-helix 5 of Bacillus thuringiensis d-endotoxins is critical for insect toxicity through ion-channel formation. We analyzed the role of the highly conserved residue Histidine 168 (H168) using molecular ...
TRPM7 mediates kidney injury, endothelial hyperpermeability and mortality during endotoxemia
(Nature Publishing Group, 2020)
Acute kidney injury and endothelial hyperpermeability are main features observed during severe sepsis with low survival rate. Transient receptor potential melastatin 7 (TRPM7) calcium channel inhibition protects against ...
Lipopolysaccharide inhibits the channel activity of the P2X7 receptor
(2011)
The purinergic P2X7 receptor (P2X7R) plays an important role during the immune response, participating in several events such
as cytokine release, apoptosis, and necrosis. The bacterial endotoxin lipopolysaccharide (LPS) ...
Is a leaky gut involved in the pathogenesis of intrahepatic cholestasis of pregnancy?
(JOHN WILEY, 2006-04)
Increased gastrointestinal permeability has been demonstrated in several liver diseases. It may facilitate the absorption of gut-derived endotoxin-stimulating Kupffer cells to release proinflammatory cytokines or other ...
Análisis genómico al azar de Edwardsiella tarda ETSJ54: anotación de genes relacionados con virulencia
(Universidad de los Llanos, 2013-01-01)
Titulo en ingles: A random genome analysis of Edwardsiella tarda ETSJ54: annotation of putative virulence- related genesTitulo en portugues: A análise do genoma aleatória de Edwardsiella tarda ETSJ54: anotação de genes ...
Lssp-pcr para la identificación de polimorfismos en el gen cry1b en cepas nativas de bacillus thuringiensis
(Universidad Nacional de Colombia, 2012)
Título en ingles: LSSP-PCR to identify polymorphisms in the gene cry1B of Bacillus thuringiensis native strain Resumen: Se estandarizó la técnica LSSP-PCR (reacción en cadena de la polimerasa con un único oligonucleótido ...