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ROLE of POSITION-9 and POSITION-10 in the ENDOTHELIN MOLECULE for BIOLOGICAL-ACTIVITY and DISCRIMINATION of RECEPTOR SUBTYPES
(Elsevier B.V., 1995-05-15)
The importance of residues 9 and 10 in endothelin-1 was assessed by studying the responses of the guinea-pig ileum to [Ala(9)]endothelin-1 and [Ala(10)]endothelin-1. Both analogues induced relaxation followed by contraction. ...
Central endothelin ETB receptor activation reduces blood pressure and catecholaminergic activity in the olfactory bulb of deoxycorticosterone acetate-salt hypertensive rats
(Elsevier Science Inc, 2020-10)
Endothelins regulate catecholaminergic activity in the olfactory bulb (OB) in normotensive and hypertensive animals. Administration of an endothelin ETA receptor antagonist decreases blood pressure in deoxycorticosterone ...
Targeting endothelin ET(A) and ET(B) receptors inhibits antigen-induced neutrophil migration and mechanical hypernociception in mice
(SPRINGER, 2009)
Endothelin may contribute to the development of inflammatory events such as leukocyte recruitment and nociception. Herein, we investigated whether endothelin-mediated mechanical hypernociception (decreased nociceptive ...
Endothelin ETA receptor antagonism attenuates the presser effects of nicotine in rats
(Elsevier Science BvAmsterdamHolanda, 2000)
Nonselective endothelin-receptor antagonism attenuates hemodynamic changes after massive pulmonary air embolism in dogs
(Amer Coll Chest PhysiciansNorthbrookEUA, 2000)
Increased cardiac sympathetic drive and reduced vagal modulation following endothelin receptor antagonism in healthy conscious rats
(WILEY-BLACKWELL, 2008)
1. The present study evaluated changes in autonomic control of the cardiovascular system in conscious rats following blockade of endothelin (ET) receptors with bosentan. 2. Rats were treated with bosentan or vehicle (5% ...
Increased endothelin-1 reactivity and endothelial dysfunction in carotid arteries from rats with hyperhomocysteinemia
(WILEY-BLACKWELL PUBLISHING, INC, 2009)
There are interactions between endothelin-1 (ET-1) and endothelial vascular injury in hyperhomocysteinemia (HHcy), but the underlying mechanisms are poorly understood. Here we evaluated the effects of HHcy on the endothelin ...