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Caveolin-1-mediated post-traditional regulation of inducible nitric oxide synthase in human colon carcinoma cells
(2002)
Reactive oxygen species are now widely recognized as important players contributing both to cell homeostasis and the development of disease. In this respect nitric oxide (NO) is no exception. The discussion here will center ...
Regulation of human luteal steroidogenesis in vitro by nitric oxide
(1998)
To evaluate the effect of nitric oxide (NO·) in human
corpus luteum (CL) function, we investigated the
expression and the presence of NO· synthase (NOS) in
the human CL and the action of NO· on the in vitro
luteal ...
N-Acetylcysteine, a glutathione precursor, reverts vascular dysfunction and endothelial epigenetic programming in intrauterine growth restricted guinea pigs
(Blackwell Publishing Ltd, 2017)
© 2016 The Authors. The Journal of Physiology © 2016 The Physiological SocietyKey points: Intrauterine growth restriction (IUGR) is associated with vascular dysfunction, oxidative stress and signs of endothelial epigenetic ...
Oxidative stress at the vascular wall. Mechanistic and pharmacological aspects
(ELSEVIER, 2006-05)
During the process of energy production in aerobic respiration, vascular cells produce reactive oxygen species (ROS). A growing body of evidence indicates that oxidative stress refers to a condition in which cells are ...
Modulatory Effect of 2-(4-Hydroxyphenyl)amino-1,4-naphthoquinone on Endothelial Vasodilation in Rat Aorta
(2016)
The vascular endotheliumplays an essential role in the control of the blood flow. Pharmacological agents like quinone (menadione) at various doses modulate this process in a variety of ways. In this study, Q7, a ...
Expression of vascular endothelial growth factor and endothelial nitric oxide synthase is increased in the placenta of sheep at high altitude in the Andes
(CANADIAN VET MED ASSOC, 2010-07)
Fetal weight and the placenta of sheep at high altitude (HA) are affected by hypoxia. Placental changes (an increase in placental size and vascularization) are greater in ewes from populations that have lived for several ...
Nitric oxide synthase inhibitor improves de novo and long-term l-DOPA-induced dyskinesia in hemiparkinsonian rats
(2011-06)
Inhibitors of neuronal and endothelial nitric oxide synthase decrease l-3,4-dihidroxifenilalanine
(l-DOPA)-induced dyskinesias in rodents. The mechanism of nitric oxide inhibitor action is
unknown. The aims of the present ...
Association of the intronic polymorphism rs891512 (G24943A) of the endothelial nitric oxide synthase gene with hypertension in Chilean type 2 diabetes patients
(2012)
We investigated two single nucleotide polymorphisms of the NOS3 gene in type 2 diabetic patients (n= 93) and healthy non-diabetic controls (n= 76) and their relationship with smoking habits, body mass index, hypertension ...
The role of the L-arginine-nitric oxide pathway in preeclampsia
(2008-08-01)
: Preeclampsia (PE) is a major cause of maternal and perinatal mortality, especially in developing countries. Its etiology involves multiple factors, but no specific cause has been identified. Evidence suggests that clinical ...
Role of adenosine transport in gestational diabetes-induced L-arginine transport and nitric oxide synthesis in human umbilical vein endothelium
(2004)
Gestational diabetes is associated with increased L-arginine transport and nitric oxide (NO) synthesis, and reduced adenosine transport in human umbilical vein endothelial cells (HUVEC). Adenosine increases endothelial ...