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Endoplasmic reticulum proteostasis impairment in aging
(Blackwell, 2017)
Perturbed neuronal proteostasis is a salient feature shared by both aging and protein misfolding disorders. The proteostasis network controls the health of the proteome by integrating pathways involved in protein synthesis, ...
Placental endoplasmic reticulum stress and acidosis: relevant aspects in gestational diabetes
(Springer Verlag Berlín, 2016-10)
In this issue, Yung and colleagues (doi: 10.1007/s00125-016-4040-2) report endoplasmic reticulum stress in the placenta of patients with gestational diabetes mellitus. With the use of a trophoblast-like cell line, these ...
Role of cerebral dopamine neurotrophic factor in endoplasmic reticulum stress
(2019)
The cerebral dopamine neurotrophic factor (CDNF) is a peptide of 187 amino acids located in the endoplasmic reticulum of numerous cell types and evolutionarily conserved. CDNF exerts a protective effect on neurons in ...
c-Abl Phosphorylates MFN2 to Regulate Mitochondrial Morphology in Cells under Endoplasmic Reticulum and Oxidative Stress, Impacting Cell Survival and Neurodegeneration
(De Gruyter, 2023)
The endoplasmic reticulum is a subcellular organelle key in the control of synthesis, folding, and sorting of proteins. Under endoplasmic reticulum stress, an adaptative unfolded protein response is activated; however, if ...
c-Abl Phosphorylates MFN2 to Regulate Mitochondrial Morphology in Cells under Endoplasmic Reticulum and Oxidative Stress, Impacting Cell Survival and Neurodegeneration
(MDPI, 2023)
The endoplasmic reticulum is a subcellular organelle key in the control of synthesis, folding, and sorting of proteins. Under endoplasmic reticulum stress, an adaptative unfolded protein response is activated; however, if ...
Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease
(Elsevier B.V., 2018)
© 2018 The global epidemic of obesity has been accompanied by a rising burden of non-alcoholic fatty liver disease (NAFLD), with manifestations ranging from simple steatosis to non-alcoholic steatohepatitis, potentially ...
Integrating stress signals at the endoplasmic reticulum: The BCL-2 protein family rheostat
(Elsevier, 2011-04)
The assembling of distinct signaling protein complexes at the endoplasmic reticulum (ER) membrane controls several stress responses related to calcium homeostasis. autophagy, ER morphogenesis and protein folding. Diverse ...